TOP1

ENSG00000198900 - H. sapiens

Pathways

Go term Description
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003917 DNA topoisomerase type I activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0003916 DNA topoisomerase activity

Drugs

Drug name Description
IRINOTECAN DNA topoisomerase I inhibitor

Diseases

Disease Name
AML*

Orthologs

Gene Organism
TOP1 S. cerevisiae
top-1 C. elegans
Top1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000198793 MTOR ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000129673 AANAT ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000117713 ARID1A ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000196712 NF1 ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000171552 BCL2L1 ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000083093 PALB2 ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000012048 BRCA1 ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000139618 BRCA2 ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000163939 PBRM1 ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000134853 PDGFRA ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000094804 CDC6 ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000102096 PIM2 ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000134371 CDC73 ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000276618 RAD17 ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000135446 CDK4 ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000185483 ROR1 ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000124762 CDKN1A ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000142534 RPS11 ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000149554 CHEK1 ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000198900 TOP1 ENSG00000165699 TSC1 H. sapiens SSL BioGRID 1.0 View
ENSG00000141736 ERBB2 ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000091483 FH ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000198900 TOP1 ENSG00000155657 TTN H. sapiens SSL BioGRID 1.0 View
ENSG00000168522 FNTA ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000198900 TOP1 ENSG00000166483 WEE1 H. sapiens SSL BioGRID 1.0 View
ENSG00000131899 LLGL1 ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000085511 MAP3K4 ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000095002 MSH2 ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000116478 HDAC1 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.989024 View
ENSG00000142208 AKT1 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.988875 View
ENSG00000077097 TOP2B ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.987169 View
ENSG00000188612 SUMO2 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.986994 View
ENSG00000012048 BRCA1 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.986738 View
ENSG00000166949 SMAD3 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.986568 View
ENSG00000124762 CDKN1A ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.986397 View
ENSG00000185591 SP1 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.986344 View
ENSG00000005339 CREBBP ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.986151 View
ENSG00000132646 PCNA ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.98591 View
ENSG00000168036 CTNNB1 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.983939 View
ENSG00000080824 HSP90AA1 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.983802 View