TOP1

ENSG00000198900 - H. sapiens

Pathways

Go term Description
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003917 DNA topoisomerase type I activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0003916 DNA topoisomerase activity

Drugs

Drug name Description
IRINOTECAN DNA topoisomerase I inhibitor

Diseases

Disease Name
AML*

Orthologs

Gene Organism
TOP1 S. cerevisiae
top-1 C. elegans
Top1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000154582 TCEB1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.953543 View
ENSG00000148737 TCF7L2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.953484 View
ENSG00000113721 PDGFRB ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.953398 View
ENSG00000112531 QKI ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.953373 View
ENSG00000120656 TAF12 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.953238 View
ENSG00000120837 NFYB ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.953179 View
ENSG00000182521 TBPL2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.953161 View
ENSG00000198900 TOP1 ENSG00000204103 MAFB H. sapiens SDL Slorth 0.953029 View
ENSG00000122257 RBBP6 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.952905 View
ENSG00000136574 GATA4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.95288 View
ENSG00000080603 SRCAP ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.952841 View
ENSG00000198900 TOP1 ENSG00000245848 CEBPA H. sapiens SSL Slorth 0.952752 View
ENSG00000080503 SMARCA2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.952587 View
ENSG00000117222 RBBP5 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.952486 View
ENSG00000167548 KMT2D ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.95247 View
ENSG00000138081 FBXO11 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.952465 View
ENSG00000140262 TCF12 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.952169 View
ENSG00000156603 MED19 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.952138 View
ENSG00000130699 TAF4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.952108 View
ENSG00000169045 HNRNPH1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.952062 View
ENSG00000083168 KAT6A ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.952032 View
ENSG00000069869 NEDD4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.95189 View
ENSG00000092201 SUPT16H ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.95184 View
ENSG00000125952 MAX ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.951791 View
ENSG00000075089 ACTR6 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.951734 View
ENSG00000049541 RFC2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.951687 View
ENSG00000198900 TOP1 ENSG00000213923 CSNK1E H. sapiens SSL Slorth 0.95163 View
ENSG00000126261 UBA2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.951612 View
ENSG00000026103 FAS ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.951597 View
ENSG00000185811 IKZF1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.951517 View
ENSG00000129993 CBFA2T3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.951499 View
ENSG00000163904 SENP2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.951496 View
ENSG00000197323 TRIM33 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.951334 View
ENSG00000078304 PPP2R5C ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.951329 View
ENSG00000175387 SMAD2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.951316 View
ENSG00000096968 JAK2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.951287 View
ENSG00000101972 STAG2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.95122 View
ENSG00000122691 TWIST1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.951155 View
ENSG00000112062 MAPK14 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.951094 View
ENSG00000196498 NCOR2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.95089 View