TOP1

ENSG00000198900 - H. sapiens

Pathways

Go term Description
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003917 DNA topoisomerase type I activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0003916 DNA topoisomerase activity

Drugs

Drug name Description
IRINOTECAN DNA topoisomerase I inhibitor

Diseases

Disease Name
AML*

Orthologs

Gene Organism
TOP1 S. cerevisiae
top-1 C. elegans
Top1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000105173 CCNE1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.947096 View
ENSG00000170860 LSM3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.946895 View
ENSG00000099381 SETD1A ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.946801 View
ENSG00000114742 WDR48 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.946764 View
ENSG00000173145 NOC3L ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.94671 View
ENSG00000187790 FANCM ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.946658 View
ENSG00000166794 PPIB ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.946579 View
ENSG00000150457 LATS2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.946496 View
ENSG00000170345 FOS ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.946486 View
ENSG00000083520 DIS3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.946483 View
ENSG00000167513 CDT1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.946323 View
ENSG00000132155 RAF1 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.94625 View
ENSG00000110395 CBL ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.946158 View
ENSG00000079277 MKNK1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.946052 View
ENSG00000106462 EZH2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.946032 View
ENSG00000168496 FEN1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.945925 View
ENSG00000107643 MAPK8 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.945874 View
ENSG00000145604 SKP2 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.945733 View
ENSG00000119487 MAPKAP1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.94573 View
ENSG00000171791 BCL2 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.945702 View
ENSG00000155827 RNF20 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.945672 View
ENSG00000134014 ELP3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.945602 View
ENSG00000198742 SMURF1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.94557 View
ENSG00000100644 HIF1A ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.945552 View
ENSG00000141564 RPTOR ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.945183 View
ENSG00000151923 TIAL1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.945144 View
ENSG00000113810 SMC4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.945117 View
ENSG00000131747 TOP2A ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.945089 View
ENSG00000096746 HNRNPH3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.945074 View
ENSG00000135341 MAP3K7 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.944864 View
ENSG00000075624 ACTB ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.9448 View
ENSG00000099804 CDC34 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.944795 View
ENSG00000130811 EIF3G ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.944721 View
ENSG00000136273 HUS1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.944523 View
ENSG00000183207 RUVBL2 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.944451 View
ENSG00000101442 ACTR5 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.944336 View
ENSG00000009413 REV3L ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.944311 View
ENSG00000198900 TOP1 ENSG00000205629 LCMT1 H. sapiens SDL Slorth 0.944293 View
ENSG00000096717 SIRT1 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.944252 View
ENSG00000106245 BUD31 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.944206 View