TOP1

ENSG00000198900 - H. sapiens

Pathways

Go term Description
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003917 DNA topoisomerase type I activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0003916 DNA topoisomerase activity

Drugs

Drug name Description
IRINOTECAN DNA topoisomerase I inhibitor

Diseases

Disease Name
AML*

Orthologs

Gene Organism
TOP1 S. cerevisiae
top-1 C. elegans
Top1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000114062 UBE3A ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.938977 View
ENSG00000164924 YWHAZ ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.938949 View
ENSG00000100906 NFKBIA ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.938851 View
ENSG00000108424 KPNB1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.938821 View
ENSG00000006451 RALA ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.938762 View
ENSG00000160294 MCM3AP ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.938743 View
ENSG00000132341 RAN ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.938722 View
ENSG00000105647 PIK3R2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.938662 View
ENSG00000143190 POU2F1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.938651 View
ENSG00000108561 C1QBP ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.938636 View
ENSG00000164134 NAA15 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.93858 View
ENSG00000119314 PTBP3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.938457 View
ENSG00000168395 ING5 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.938265 View
ENSG00000198522 GPN1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.93821 View
ENSG00000086065 CHMP5 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.938127 View
ENSG00000168438 CDC40 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.938032 View
ENSG00000187840 EIF4EBP1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.938018 View
ENSG00000157106 SMG1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.938008 View
ENSG00000073584 SMARCE1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.937946 View
ENSG00000142875 PRKACB ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.937923 View
ENSG00000102882 MAPK3 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.937852 View
ENSG00000148229 POLE3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.937834 View
ENSG00000126934 MAP2K2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.937792 View
ENSG00000197780 TAF13 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.93769 View
ENSG00000121022 COPS5 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.937624 View
ENSG00000157764 BRAF ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.937569 View
ENSG00000137413 TAF8 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.937459 View
ENSG00000101811 CSTF2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.937402 View
ENSG00000177889 UBE2N ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.937369 View
ENSG00000132612 VPS4A ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.937352 View
ENSG00000123349 PFDN5 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.937336 View
ENSG00000036257 CUL3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.937293 View
ENSG00000136807 CDK9 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.937176 View
ENSG00000116459 ATP5F1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.937131 View
ENSG00000092847 AGO1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.936964 View
ENSG00000184557 SOCS3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.93694 View
ENSG00000153147 SMARCA5 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.936881 View
ENSG00000102978 POLR2C ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.93677 View
ENSG00000149311 ATM ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.936746 View
ENSG00000080986 NDC80 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.936662 View