TOP1

ENSG00000198900 - H. sapiens

Pathways

Go term Description
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003917 DNA topoisomerase type I activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0003916 DNA topoisomerase activity

Drugs

Drug name Description
IRINOTECAN DNA topoisomerase I inhibitor

Diseases

Disease Name
AML*

Orthologs

Gene Organism
TOP1 S. cerevisiae
top-1 C. elegans
Top1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000123374 CDK2 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.98363 View
ENSG00000141510 TP53 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.983015 View
ENSG00000100393 EP300 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.982794 View
ENSG00000150991 UBC ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.982081 View
ENSG00000134086 VHL ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.981914 View
ENSG00000149554 CHEK1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.981744 View
ENSG00000091831 ESR1 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.980746 View
ENSG00000139687 RB1 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.980508 View
ENSG00000101266 CSNK2A1 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.98025 View
ENSG00000197122 SRC ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.979881 View
ENSG00000121022 COPS5 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.97861 View
ENSG00000123374 CDK2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.978428 View
ENSG00000169375 SIN3A ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.978399 View
ENSG00000111276 CDKN1B ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.978351 View
ENSG00000140464 PML ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.978185 View
ENSG00000177606 JUN ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.977983 View
ENSG00000149311 ATM ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.97798 View
ENSG00000142208 AKT1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.977844 View
ENSG00000101266 CSNK2A1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.977818 View
ENSG00000132383 RPA1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.977814 View
ENSG00000166949 SMAD3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.977675 View
ENSG00000164305 CASP3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.977575 View
ENSG00000112062 MAPK14 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.97757 View
ENSG00000185591 SP1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.977516 View
ENSG00000130726 TRIM28 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.977457 View
ENSG00000162385 MAGOH ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.977344 View
ENSG00000141027 NCOR1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.977211 View
ENSG00000139687 RB1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.977173 View
ENSG00000172977 KAT5 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.977137 View
ENSG00000101412 E2F1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.977134 View
ENSG00000005339 CREBBP ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.976818 View
ENSG00000103275 UBE2I ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.976787 View
ENSG00000170315 UBB ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.976687 View
ENSG00000133703 KRAS ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.976622 View
ENSG00000161057 PSMC2 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.976397 View
ENSG00000136997 MYC ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.976391 View
ENSG00000177606 JUN ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.976274 View
ENSG00000173039 RELA ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.976073 View
ENSG00000141646 SMAD4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.976071 View
ENSG00000175104 TRAF6 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.976042 View