TOP1

ENSG00000198900 - H. sapiens

Pathways

Go term Description
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003917 DNA topoisomerase type I activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0003916 DNA topoisomerase activity

Drugs

Drug name Description
IRINOTECAN DNA topoisomerase I inhibitor

Diseases

Disease Name
AML*

Orthologs

Gene Organism
TOP1 S. cerevisiae
top-1 C. elegans
Top1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000136518 ACTL6A ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.962985 View
ENSG00000167670 CHAF1A ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.96296 View
ENSG00000104738 MCM4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.962937 View
ENSG00000113575 PPP2CA ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.962929 View
ENSG00000123358 NR4A1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.962851 View
ENSG00000116604 MEF2D ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.962814 View
ENSG00000128908 INO80 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.962789 View
ENSG00000041357 PSMA4 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.962783 View
ENSG00000104365 IKBKB ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.962678 View
ENSG00000149273 RPS3 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.962435 View
ENSG00000127337 YEATS4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.962307 View
ENSG00000165280 VCP ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.96221 View
ENSG00000132383 RPA1 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.962199 View
ENSG00000087586 AURKA ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.962085 View
ENSG00000110092 CCND1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.961698 View
ENSG00000176208 ATAD5 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.961622 View
ENSG00000198900 TOP1 ENSG00000213949 ITGA1 H. sapiens SDL Slorth 0.961613 View
ENSG00000166851 PLK1 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.961427 View
ENSG00000141867 BRD4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.961281 View
ENSG00000170365 SMAD1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.961217 View
ENSG00000071242 RPS6KA2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.961173 View
ENSG00000117748 RPA2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.961164 View
ENSG00000138376 BARD1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.960841 View
ENSG00000197299 BLM ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.960782 View
ENSG00000196284 SUPT3H ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.960603 View
ENSG00000136936 XPA ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.960545 View
ENSG00000198900 TOP1 ENSG00000213341 CHUK H. sapiens SSL Slorth 0.960484 View
ENSG00000101868 POLA1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.960445 View
ENSG00000096384 HSP90AB1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.960353 View
ENSG00000109971 HSPA8 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.960349 View
ENSG00000070950 RAD18 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.960332 View
ENSG00000002016 RAD52 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.960233 View
ENSG00000100603 SNW1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.960137 View
ENSG00000004700 RECQL ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.959999 View
ENSG00000196235 SUPT5H ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.959821 View
ENSG00000123124 WWP1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.959628 View
ENSG00000187608 ISG15 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.959534 View
ENSG00000164305 CASP3 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.959497 View
ENSG00000198900 TOP1 ENSG00000253729 PRKDC H. sapiens SSL Slorth 0.959362 View
ENSG00000051180 RAD51 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.959227 View