TOP1

ENSG00000198900 - H. sapiens

Pathways

Go term Description
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003917 DNA topoisomerase type I activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0003916 DNA topoisomerase activity

Drugs

Drug name Description
IRINOTECAN DNA topoisomerase I inhibitor

Diseases

Disease Name
AML*

Orthologs

Gene Organism
TOP1 S. cerevisiae
top-1 C. elegans
Top1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000173039 RELA ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.971197 View
ENSG00000136997 MYC ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.971101 View
ENSG00000121774 KHDRBS1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.970626 View
ENSG00000171132 PRKCE ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.970518 View
ENSG00000187555 USP7 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.970492 View
ENSG00000170312 CDK1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.970332 View
ENSG00000167491 GATAD2A ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.970234 View
ENSG00000131759 RARA ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.970184 View
ENSG00000082898 XPO1 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.970073 View
ENSG00000171148 TADA3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.969992 View
ENSG00000198668 CALM1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.969967 View
ENSG00000124762 CDKN1A ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.969806 View
ENSG00000113456 RAD1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.969421 View
ENSG00000139618 BRCA2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.969276 View
ENSG00000010810 FYN ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.969162 View
ENSG00000119048 UBE2B ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.968997 View
ENSG00000004897 CDC27 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.968571 View
ENSG00000115942 ORC2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.9682 View
ENSG00000053900 ANAPC4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.968075 View
ENSG00000167986 DDB1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.968016 View
ENSG00000127586 CHTF18 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.96799 View
ENSG00000169679 BUB1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.967866 View
ENSG00000181555 SETD2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.967787 View
ENSG00000170473 PYM1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.967378 View
ENSG00000005007 UPF1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.967366 View
ENSG00000143799 PARP1 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.967146 View
ENSG00000114166 KAT2B ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.967119 View
ENSG00000103194 USP10 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.967113 View
ENSG00000196591 HDAC2 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.967097 View
ENSG00000136875 PRPF4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.967066 View
ENSG00000146648 EGFR ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.966854 View
ENSG00000123200 ZC3H13 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.966628 View
ENSG00000172845 SP3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.96642 View
ENSG00000147133 TAF1 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.966258 View
ENSG00000133101 CCNA1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.966242 View
ENSG00000135521 LTV1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.966183 View
ENSG00000113812 ACTR8 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.966149 View
ENSG00000110092 CCND1 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.966147 View
ENSG00000135446 CDK4 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.966121 View
ENSG00000168610 STAT3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.96611 View