TOP1

ENSG00000198900 - H. sapiens

Pathways

Go term Description
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003917 DNA topoisomerase type I activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0003916 DNA topoisomerase activity

Drugs

Drug name Description
IRINOTECAN DNA topoisomerase I inhibitor

Diseases

Disease Name
AML*

Orthologs

Gene Organism
TOP1 S. cerevisiae
top-1 C. elegans
Top1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000007047 MARK4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.756171 View
ENSG00000100823 APEX1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.756148 View
ENSG00000122958 VPS26A ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.755937 View
ENSG00000114650 SCAP ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.755342 View
ENSG00000173846 PLK3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.75506 View
ENSG00000152137 HSPB8 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.754802 View
ENSG00000073350 LLGL2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.754782 View
ENSG00000121989 ACVR2A ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.754747 View
ENSG00000128708 HAT1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.754729 View
ENSG00000100038 TOP3B ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.754269 View
ENSG00000111348 ARHGDIB ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.753926 View
ENSG00000163527 STT3B ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.753808 View
ENSG00000106615 RHEB ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.753576 View
ENSG00000110435 PDHX ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.75352 View
ENSG00000198900 TOP1 ENSG00000221914 PPP2R2A H. sapiens SSL Slorth 0.753001 View
ENSG00000048392 RRM2B ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.752729 View
ENSG00000102753 KPNA3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.752459 View
ENSG00000086200 IPO11 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.752387 View
ENSG00000084073 ZMPSTE24 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.75238 View
ENSG00000134323 MYCN ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.752361 View
ENSG00000087460 GNAS ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.752128 View
ENSG00000171223 JUNB ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.752091 View
ENSG00000177879 AP3S1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.752053 View
ENSG00000126070 AGO3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.752024 View
ENSG00000151348 EXT2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.75183 View
ENSG00000111737 RAB35 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.75183 View
ENSG00000196961 AP2A1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.751782 View
ENSG00000070808 CAMK2A ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.751501 View
ENSG00000145817 YIPF5 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.751134 View
ENSG00000105063 PPP6R1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.750758 View
ENSG00000019582 CD74 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.750726 View