TOP1

ENSG00000198900 - H. sapiens

Pathways

Go term Description
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003917 DNA topoisomerase type I activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0003916 DNA topoisomerase activity

Drugs

Drug name Description
IRINOTECAN DNA topoisomerase I inhibitor

Diseases

Disease Name
AML*

Orthologs

Gene Organism
TOP1 S. cerevisiae
top-1 C. elegans
Top1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000153015 CWC27 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.790486 View
ENSG00000037280 FLT4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.790356 View
ENSG00000178921 PFAS ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.790186 View
ENSG00000116584 ARHGEF2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.789876 View
ENSG00000169016 E2F6 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.789849 View
ENSG00000163902 RPN1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.789569 View
ENSG00000182400 TRAPPC6B ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.789486 View
ENSG00000154174 TOMM70 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.789314 View
ENSG00000136271 DDX56 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.789203 View
ENSG00000013275 PSMC4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.789126 View
ENSG00000151148 UBE3B ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.789107 View
ENSG00000134243 SORT1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.789042 View
ENSG00000138794 CASP6 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.788616 View
ENSG00000169230 PRELID1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.788585 View
ENSG00000133627 ACTR3B ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.788579 View
ENSG00000119383 PTPA ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.788421 View
ENSG00000060971 ACAA1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.788415 View
ENSG00000147130 ZMYM3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.788085 View
ENSG00000083544 TDRD3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.787933 View
ENSG00000128829 EIF2AK4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.787836 View
ENSG00000129219 PLD2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.787392 View
ENSG00000166902 MRPL16 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.787246 View
ENSG00000125814 NAPB ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.786936 View
ENSG00000041357 PSMA4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.786705 View
ENSG00000111450 STX2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.786511 View
ENSG00000104313 EYA1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.785981 View
ENSG00000180098 TRNAU1AP ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.785795 View
ENSG00000044524 EPHA3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.785708 View
ENSG00000138190 EXOC6 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.785311 View
ENSG00000144036 EXOC6B ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.785311 View
ENSG00000113140 SPARC ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.785257 View
ENSG00000100417 PMM1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.785086 View
ENSG00000003436 TFPI ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.784975 View
ENSG00000142731 PLK4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.784832 View
ENSG00000103769 RAB11A ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.784728 View
ENSG00000078674 PCM1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.784719 View
ENSG00000196576 PLXNB2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.78463 View
ENSG00000074201 CLNS1A ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.784622 View
ENSG00000163083 INHBB ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.78453 View
ENSG00000070018 LRP6 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.784305 View