TOP1

ENSG00000198900 - H. sapiens

Pathways

Go term Description
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003917 DNA topoisomerase type I activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0003916 DNA topoisomerase activity

Drugs

Drug name Description
IRINOTECAN DNA topoisomerase I inhibitor

Diseases

Disease Name
AML*

Orthologs

Gene Organism
TOP1 S. cerevisiae
top-1 C. elegans
Top1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000178607 ERN1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.80596 View
ENSG00000011260 UTP18 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.805927 View
ENSG00000145741 BTF3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.805757 View
ENSG00000148943 LIN7C ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.805672 View
ENSG00000166803 KIAA0101 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.805259 View
ENSG00000155438 NIFK ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.805136 View
ENSG00000184110 EIF3C ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.804765 View
ENSG00000143970 ASXL2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.804611 View
ENSG00000171608 PIK3CD ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.804611 View
ENSG00000122545 SEPT7 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.804506 View
ENSG00000091164 TXNL1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.804386 View
ENSG00000112290 WASF1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.804333 View
ENSG00000175354 PTPN2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.804287 View
ENSG00000111642 CHD4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.804125 View
ENSG00000152684 PELO ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.803995 View
ENSG00000183431 SF3A3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.803015 View
ENSG00000145388 METTL14 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.802934 View
ENSG00000174791 RIN1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.80293 View
ENSG00000115866 DARS ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.802843 View
ENSG00000198431 TXNRD1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.802727 View
ENSG00000033627 ATP6V0A1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.802683 View
ENSG00000196781 TLE1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.802616 View
ENSG00000167996 FTH1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.802327 View
ENSG00000111786 SRSF9 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.802048 View
ENSG00000072134 EPN2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.801858 View
ENSG00000099940 SNAP29 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.801672 View
ENSG00000163938 GNL3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.801581 View
ENSG00000072364 AFF4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.801559 View
ENSG00000047410 TPR ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.801486 View
ENSG00000049245 VAMP3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.801482 View
ENSG00000128340 RAC2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.801361 View
ENSG00000149084 HSD17B12 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.801273 View
ENSG00000058262 SEC61A1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.801269 View
ENSG00000180104 EXOC3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.800991 View
ENSG00000109606 DHX15 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.800812 View
ENSG00000182481 KPNA2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.800672 View
ENSG00000108883 EFTUD2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.800551 View
ENSG00000157554 ERG ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.800518 View
ENSG00000116141 MARK1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.800458 View
ENSG00000173545 ZNF622 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.800236 View