ERN1 - TOP1

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
ERN1	ENSG00000178607	No diseases in record	No drugs in record	magnesium ion binding endoribonuclease activity protein serine/threonine kinase activity platelet-derived growth factor receptor binding protein binding ATP binding enzyme binding Hsp70 protein binding identical protein binding protein homodimerization activity ADP binding Hsp90 protein binding	IRE1 (S. cerevisiae) ire-1 (C. elegans) Ire1 (D. melanogaster)
TOP1	ENSG00000198900	AML*	IRINOTECAN	core promoter sequence-specific DNA binding DNA binding chromatin binding DNA topoisomerase type I activity protein binding isomerase activity DNA topoisomerase activity	TOP1 (S. cerevisiae) top-1 (C. elegans) Top1 (D. melanogaster)