TOP1

ENSG00000198900 - H. sapiens

Pathways

Go term Description
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003917 DNA topoisomerase type I activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0003916 DNA topoisomerase activity

Drugs

Drug name Description
IRINOTECAN DNA topoisomerase I inhibitor

Diseases

Disease Name
AML*

Orthologs

Gene Organism
TOP1 S. cerevisiae
top-1 C. elegans
Top1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000164815 ORC5 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.95642 View
ENSG00000049618 ARID1B ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.956409 View
ENSG00000048052 HDAC9 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.956272 View
ENSG00000165119 HNRNPK ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.956252 View
ENSG00000101146 RAE1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.956165 View
ENSG00000070770 CSNK2A2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.955933 View
ENSG00000148835 TAF5 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.95581 View
ENSG00000001167 NFYA ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.955742 View
ENSG00000134982 APC ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.955653 View
ENSG00000068305 MEF2A ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.955512 View
ENSG00000105810 CDK6 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.955478 View
ENSG00000164941 INTS8 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.9554 View
ENSG00000113722 CDX1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.955392 View
ENSG00000147133 TAF1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.955392 View
ENSG00000138663 COPS4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.955335 View
ENSG00000100142 POLR2F ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.955288 View
ENSG00000133895 MEN1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.955232 View
ENSG00000099956 SMARCB1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.955175 View
ENSG00000102054 RBBP7 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.955128 View
ENSG00000119772 DNMT3A ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.955107 View
ENSG00000164867 NOS3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.954975 View
ENSG00000129691 ASH2L ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.954974 View
ENSG00000115053 NCL ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.954846 View
ENSG00000149923 PPP4C ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.954827 View
ENSG00000149136 SSRP1 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.95477 View
ENSG00000145216 FIP1L1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.954592 View
ENSG00000135018 UBQLN1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.954497 View
ENSG00000088833 NSFL1C ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.954491 View
ENSG00000172531 PPP1CA ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.954465 View
ENSG00000145604 SKP2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.954331 View
ENSG00000099956 SMARCB1 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.95432 View
ENSG00000163932 PRKCD ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.954185 View
ENSG00000177885 GRB2 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.954103 View
ENSG00000101665 SMAD7 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.953889 View
ENSG00000133226 SRRM1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.953886 View
ENSG00000093009 CDC45 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.953782 View
ENSG00000174405 LIG4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.95368 View
ENSG00000169251 NMD3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.953625 View
ENSG00000117676 RPS6KA1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.953604 View
ENSG00000134058 CDK7 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.953591 View