TOP1

ENSG00000198900 - H. sapiens

Pathways

Go term Description
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003917 DNA topoisomerase type I activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0003916 DNA topoisomerase activity

Drugs

Drug name Description
IRINOTECAN DNA topoisomerase I inhibitor

Diseases

Disease Name
AML*

Orthologs

Gene Organism
TOP1 S. cerevisiae
top-1 C. elegans
Top1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000073111 MCM2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.965833 View
ENSG00000082898 XPO1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.965802 View
ENSG00000167552 TUBA1A ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.965793 View
ENSG00000148400 NOTCH1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.965502 View
ENSG00000079387 SENP1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.965296 View
ENSG00000109971 HSPA8 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.965275 View
ENSG00000198612 COPS8 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.965122 View
ENSG00000106355 LSM5 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.965051 View
ENSG00000188739 RBM34 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.96489 View
ENSG00000166167 BTRC ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.964759 View
ENSG00000070010 UFD1L ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.964577 View
ENSG00000062650 WAPL ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.964533 View
ENSG00000181163 NPM1 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.964421 View
ENSG00000111875 ASF1A ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.964377 View
ENSG00000055332 EIF2AK2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.964242 View
ENSG00000097046 CDC7 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.96416 View
ENSG00000168283 BMI1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.96412 View
ENSG00000082701 GSK3B ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.963857 View
ENSG00000084676 NCOA1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.963814 View
ENSG00000119541 VPS4B ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.963805 View
ENSG00000132341 RAN ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.963543 View
ENSG00000106588 PSMA2 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.963509 View
ENSG00000162231 NXF1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.963497 View
ENSG00000112118 MCM3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.963464 View
ENSG00000082701 GSK3B ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.963398 View
ENSG00000079102 RUNX1T1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.963361 View
ENSG00000081189 MEF2C ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.963344 View
ENSG00000170312 CDK1 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.963341 View
ENSG00000183684 ALYREF ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.96331 View
ENSG00000166167 BTRC ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.963252 View
ENSG00000175104 TRAF6 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.963179 View
ENSG00000118046 STK11 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.963125 View
ENSG00000166851 PLK1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.963084 View
ENSG00000168883 USP39 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.963077 View
ENSG00000171791 BCL2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.963077 View
ENSG00000108443 RPS6KB1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.963051 View
ENSG00000136527 TRA2B ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.963028 View
ENSG00000113558 SKP1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.963027 View
ENSG00000094916 CBX5 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.963021 View
ENSG00000097007 ABL1 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.962996 View