TOP1

ENSG00000198900 - H. sapiens

Pathways

Go term Description
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003917 DNA topoisomerase type I activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0003916 DNA topoisomerase activity

Drugs

Drug name Description
IRINOTECAN DNA topoisomerase I inhibitor

Diseases

Disease Name
AML*

Orthologs

Gene Organism
TOP1 S. cerevisiae
top-1 C. elegans
Top1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000099817 POLR2E ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.959222 View
ENSG00000130382 MLLT1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.959185 View
ENSG00000140464 PML ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.959149 View
ENSG00000177889 UBE2N ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.959123 View
ENSG00000112576 CCND3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.959015 View
ENSG00000176749 CDK5R1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.958982 View
ENSG00000178028 DMAP1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.958905 View
ENSG00000137815 RTF1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.958835 View
ENSG00000106290 TAF6 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.958804 View
ENSG00000166913 YWHAB ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.958705 View
ENSG00000131747 TOP2A ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.958685 View
ENSG00000132155 RAF1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.958605 View
ENSG00000132646 PCNA ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.958569 View
ENSG00000164885 CDK5 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.958438 View
ENSG00000165025 SYK ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.958247 View
ENSG00000177426 TGIF1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.958227 View
ENSG00000169139 UBE2V2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.958114 View
ENSG00000184900 SUMO3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.957858 View
ENSG00000175595 ERCC4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.957827 View
ENSG00000177885 GRB2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.9578 View
ENSG00000175054 ATR ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.95777 View
ENSG00000165392 WRN ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.957703 View
ENSG00000076242 MLH1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.95767 View
ENSG00000137486 ARRB1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.957658 View
ENSG00000091831 ESR1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.957608 View
ENSG00000184900 SUMO3 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.957582 View
ENSG00000149136 SSRP1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.957499 View
ENSG00000197122 SRC ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.95736 View
ENSG00000127511 SIN3B ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.95734 View
ENSG00000160214 RRP1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.957218 View
ENSG00000118260 CREB1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.957106 View
ENSG00000055130 CUL1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.957092 View
ENSG00000171843 MLLT3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.957075 View
ENSG00000141027 NCOR1 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.957013 View
ENSG00000062822 POLD1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.956997 View
ENSG00000071564 TCF3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.956991 View
ENSG00000147536 GINS4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.956986 View
ENSG00000185338 SOCS1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.956954 View
ENSG00000132326 PER2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.956633 View
ENSG00000164885 CDK5 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.956632 View