TOP2A

ENSG00000131747 - H. sapiens

Pathways

Go term Description
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0008144 drug binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
DAUNORUBICIN DNA topoisomerase II alpha inhibitor
DOXORUBICIN DNA topoisomerase II alpha inhibitor
EPIRUBICIN
ETOPOSIDE DNA topoisomerase II inhibitor
ETOPOSIDE PHOSPHATE DNA topoisomerase II alpha inhibitor
IDARUBICIN DNA topoisomerase II alpha inhibitor
MITOXANTRONE
PODOFILOX
TENIPOSIDE DNA topoisomerase II inhibitor
VALRUBICIN DNA topoisomerase II alpha inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000149554 CHEK1 ENSG00000131747 TOP2A H. sapiens SSL BioGRID 1.0 View
ENSG00000091483 FH ENSG00000131747 TOP2A H. sapiens SSL BioGRID 1.0 View
ENSG00000131899 LLGL1 ENSG00000131747 TOP2A H. sapiens SSL BioGRID 1.0 View
ENSG00000085511 MAP3K4 ENSG00000131747 TOP2A H. sapiens SSL BioGRID 1.0 View
ENSG00000095002 MSH2 ENSG00000131747 TOP2A H. sapiens SSL BioGRID 1.0 View
ENSG00000196712 NF1 ENSG00000131747 TOP2A H. sapiens SSL BioGRID 1.0 View
ENSG00000083093 PALB2 ENSG00000131747 TOP2A H. sapiens SSL BioGRID 1.0 View
ENSG00000276618 RAD17 ENSG00000131747 TOP2A H. sapiens SSL BioGRID 1.0 View
ENSG00000142534 RPS11 ENSG00000131747 TOP2A H. sapiens SSL BioGRID 1.0 View
ENSG00000131747 TOP2A ENSG00000155657 TTN H. sapiens SSL BioGRID 1.0 View
ENSG00000131747 TOP2A ENSG00000166483 WEE1 H. sapiens SSL BioGRID 1.0 View
ENSG00000139618 BRCA2 ENSG00000131747 TOP2A H. sapiens SSL BioGRID 1.0 View
ENSG00000094804 CDC6 ENSG00000131747 TOP2A H. sapiens SSL BioGRID 1.0 View
ENSG00000134371 CDC73 ENSG00000131747 TOP2A H. sapiens SSL BioGRID 1.0 View
ENSG00000012048 BRCA1 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.98872 View
ENSG00000116478 HDAC1 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.986132 View
ENSG00000100393 EP300 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.986074 View
ENSG00000005339 CREBBP ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.985565 View
ENSG00000080824 HSP90AA1 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.981837 View
ENSG00000109670 FBXW7 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.981501 View
ENSG00000101412 E2F1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.979457 View
ENSG00000112062 MAPK14 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.978827 View
ENSG00000091831 ESR1 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.978626 View
ENSG00000121022 COPS5 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.978009 View
ENSG00000112592 TBP ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.97778 View
ENSG00000103275 UBE2I ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.977303 View
ENSG00000131747 TOP2A ENSG00000184428 TOP1MT H. sapiens SDL Slorth 0.977027 View
ENSG00000005339 CREBBP ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.976352 View
ENSG00000101966 XIAP ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.976288 View
ENSG00000101266 CSNK2A1 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.975635 View
ENSG00000101266 CSNK2A1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.975338 View
ENSG00000097007 ABL1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.974718 View
ENSG00000102882 MAPK3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.974607 View
ENSG00000096717 SIRT1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.974569 View
ENSG00000012048 BRCA1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.974228 View
ENSG00000116030 SUMO1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.974128 View
ENSG00000101146 RAE1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.974119 View
ENSG00000111276 CDKN1B ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.974036 View
ENSG00000130726 TRIM28 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.973998 View
ENSG00000131747 TOP2A ENSG00000169926 KLF13 H. sapiens SDL Slorth 0.973502 View