TOP2A

ENSG00000131747 - H. sapiens

Pathways

Go term Description
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0008144 drug binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
DAUNORUBICIN DNA topoisomerase II alpha inhibitor
DOXORUBICIN DNA topoisomerase II alpha inhibitor
EPIRUBICIN
ETOPOSIDE DNA topoisomerase II inhibitor
ETOPOSIDE PHOSPHATE DNA topoisomerase II alpha inhibitor
IDARUBICIN DNA topoisomerase II alpha inhibitor
MITOXANTRONE
PODOFILOX
TENIPOSIDE DNA topoisomerase II inhibitor
VALRUBICIN DNA topoisomerase II alpha inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000131747 TOP2A ENSG00000149311 ATM H. sapiens SSL Slorth 0.949711 View
ENSG00000131747 TOP2A ENSG00000167513 CDT1 H. sapiens SSL Slorth 0.949687 View
ENSG00000131747 TOP2A ENSG00000132005 RFX1 H. sapiens SDL Slorth 0.949596 View
ENSG00000131747 TOP2A ENSG00000134057 CCNB1 H. sapiens SSL Slorth 0.949586 View
ENSG00000131747 TOP2A ENSG00000136997 MYC H. sapiens SDL Slorth 0.94942 View
ENSG00000131747 TOP2A ENSG00000177302 TOP3A H. sapiens SDL Slorth 0.949397 View
ENSG00000053900 ANAPC4 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.948979 View
ENSG00000131747 TOP2A ENSG00000165392 WRN H. sapiens SDL Slorth 0.948744 View
ENSG00000131747 TOP2A ENSG00000181163 NPM1 H. sapiens SSL Slorth 0.948729 View
ENSG00000131747 TOP2A ENSG00000197299 BLM H. sapiens SSL Slorth 0.948519 View
ENSG00000001626 CFTR ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.948442 View
ENSG00000131747 TOP2A ENSG00000184675 AMER1 H. sapiens SDL Slorth 0.948309 View
ENSG00000131747 TOP2A ENSG00000144668 ITGA9 H. sapiens SDL Slorth 0.94804 View
ENSG00000131747 TOP2A ENSG00000160007 ARHGAP35 H. sapiens SDL Slorth 0.948005 View
ENSG00000129152 MYOD1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.947881 View
ENSG00000131747 TOP2A ENSG00000134954 ETS1 H. sapiens SSL Slorth 0.947752 View
ENSG00000131747 TOP2A ENSG00000178568 ERBB4 H. sapiens SSL Slorth 0.947604 View
ENSG00000113558 SKP1 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.947488 View
ENSG00000131747 TOP2A ENSG00000140464 PML H. sapiens SDL Slorth 0.947455 View
ENSG00000118260 CREB1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.947203 View
ENSG00000109320 NFKB1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.947144 View
ENSG00000131747 TOP2A ENSG00000138376 BARD1 H. sapiens SSL Slorth 0.947104 View
ENSG00000096717 SIRT1 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.947097 View
ENSG00000131747 TOP2A ENSG00000169554 ZEB2 H. sapiens SDL Slorth 0.947032 View
ENSG00000131747 TOP2A ENSG00000167986 DDB1 H. sapiens SSL Slorth 0.947022 View
ENSG00000131747 TOP2A ENSG00000187555 USP7 H. sapiens SSL Slorth 0.946961 View
ENSG00000100644 HIF1A ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.946769 View
ENSG00000084774 CAD ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.946721 View
ENSG00000131747 TOP2A ENSG00000137265 IRF4 H. sapiens SDL Slorth 0.946701 View
ENSG00000131747 TOP2A ENSG00000159692 CTBP1 H. sapiens SSL Slorth 0.94667 View
ENSG00000100603 SNW1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.946655 View
ENSG00000127337 YEATS4 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.946501 View
ENSG00000107581 EIF3A ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.946252 View
ENSG00000124813 RUNX2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.946145 View
ENSG00000131747 TOP2A ENSG00000149136 SSRP1 H. sapiens SDL Slorth 0.94614 View
ENSG00000131747 TOP2A ENSG00000135018 UBQLN1 H. sapiens SSL Slorth 0.946073 View
ENSG00000131747 TOP2A ENSG00000177981 ASB8 H. sapiens SDL Slorth 0.946036 View
ENSG00000131747 TOP2A ENSG00000139318 DUSP6 H. sapiens SDL Slorth 0.945985 View
ENSG00000079999 KEAP1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.945945 View
ENSG00000080824 HSP90AA1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.945759 View