WRN

ENSG00000165392 - H. sapiens

Pathways

Go term Description
GO:0000287 magnesium ion binding
GO:0000403 Y-form DNA binding
GO:0000405 bubble DNA binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003682 chromatin binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0004386 helicase activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008408 3'-5' exonuclease activity
GO:0009378 four-way junction helicase activity
GO:0016887 ATPase activity
GO:0030145 manganese ion binding
GO:0032403 protein complex binding
GO:0042803 protein homodimerization activity
GO:0043138 3'-5' DNA helicase activity
GO:0043140 ATP-dependent 3'-5' DNA helicase activity
GO:0051880 G-quadruplex DNA binding

Drugs

No drugs in record

Diseases

Disease Name
osteosarcoma
meningioma
other tumour types

Orthologs

Gene Organism
SGS1 S. cerevisiae
wrn-1 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000149554 CHEK1 ENSG00000165392 WRN H. sapiens SSL BioGRID 1.0 View
ENSG00000183765 CHEK2 ENSG00000165392 WRN H. sapiens SSL BioGRID 1.0 View
ENSG00000167552 TUBA1A ENSG00000165392 WRN H. sapiens SSL BioGRID 1.0 View
ENSG00000166483 WEE1 ENSG00000165392 WRN H. sapiens SSL BioGRID 1.0 View
ENSG00000150991 UBC ENSG00000165392 WRN H. sapiens SDL Slorth 0.989995 View
ENSG00000116478 HDAC1 ENSG00000165392 WRN H. sapiens SDL Slorth 0.988604 View
ENSG00000005339 CREBBP ENSG00000165392 WRN H. sapiens SDL Slorth 0.987762 View
ENSG00000012048 BRCA1 ENSG00000165392 WRN H. sapiens SDL Slorth 0.986546 View
ENSG00000100393 EP300 ENSG00000165392 WRN H. sapiens SDL Slorth 0.986112 View
ENSG00000141510 TP53 ENSG00000165392 WRN H. sapiens SDL Slorth 0.984215 View
ENSG00000133703 KRAS ENSG00000165392 WRN H. sapiens SSL Slorth 0.982093 View
ENSG00000077097 TOP2B ENSG00000165392 WRN H. sapiens SDL Slorth 0.981794 View
ENSG00000132646 PCNA ENSG00000165392 WRN H. sapiens SDL Slorth 0.980543 View
ENSG00000082701 GSK3B ENSG00000165392 WRN H. sapiens SSL Slorth 0.980468 View
ENSG00000109670 FBXW7 ENSG00000165392 WRN H. sapiens SSL Slorth 0.980444 View
ENSG00000136997 MYC ENSG00000165392 WRN H. sapiens SSL Slorth 0.97934 View
ENSG00000121022 COPS5 ENSG00000165392 WRN H. sapiens SSL Slorth 0.979063 View
ENSG00000142208 AKT1 ENSG00000165392 WRN H. sapiens SSL Slorth 0.97856 View
ENSG00000080824 HSP90AA1 ENSG00000165392 WRN H. sapiens SDL Slorth 0.978485 View
ENSG00000112062 MAPK14 ENSG00000165392 WRN H. sapiens SSL Slorth 0.978276 View
ENSG00000164924 YWHAZ ENSG00000165392 WRN H. sapiens SSL Slorth 0.978174 View
ENSG00000091831 ESR1 ENSG00000165392 WRN H. sapiens SDL Slorth 0.977722 View
ENSG00000149554 CHEK1 ENSG00000165392 WRN H. sapiens SSL Slorth 0.97752 View
ENSG00000005339 CREBBP ENSG00000165392 WRN H. sapiens SSL Slorth 0.977483 View
ENSG00000103275 UBE2I ENSG00000165392 WRN H. sapiens SSL Slorth 0.977465 View
ENSG00000141646 SMAD4 ENSG00000165392 WRN H. sapiens SSL Slorth 0.977437 View
ENSG00000112592 TBP ENSG00000165392 WRN H. sapiens SSL Slorth 0.977334 View
ENSG00000135486 HNRNPA1 ENSG00000165392 WRN H. sapiens SSL Slorth 0.977225 View
ENSG00000101966 XIAP ENSG00000165392 WRN H. sapiens SSL Slorth 0.977176 View
ENSG00000012048 BRCA1 ENSG00000165392 WRN H. sapiens SSL Slorth 0.976969 View
ENSG00000116030 SUMO1 ENSG00000165392 WRN H. sapiens SSL Slorth 0.97664 View
ENSG00000135446 CDK4 ENSG00000165392 WRN H. sapiens SSL Slorth 0.97648 View
ENSG00000100030 MAPK1 ENSG00000165392 WRN H. sapiens SSL Slorth 0.976071 View
ENSG00000132383 RPA1 ENSG00000165392 WRN H. sapiens SSL Slorth 0.976007 View
ENSG00000159692 CTBP1 ENSG00000165392 WRN H. sapiens SSL Slorth 0.975962 View
ENSG00000143799 PARP1 ENSG00000165392 WRN H. sapiens SDL Slorth 0.975785 View
ENSG00000096717 SIRT1 ENSG00000165392 WRN H. sapiens SSL Slorth 0.97489 View
ENSG00000111276 CDKN1B ENSG00000165392 WRN H. sapiens SSL Slorth 0.974787 View
ENSG00000131759 RARA ENSG00000165392 WRN H. sapiens SSL Slorth 0.974744 View
ENSG00000149311 ATM ENSG00000165392 WRN H. sapiens SSL Slorth 0.974694 View