CDK4

ENSG00000135446 - H. sapiens

Pathways

Go term Description
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
GO:0030332 cyclin binding
GO:0032403 protein complex binding
GO:0004674 protein serine/threonine kinase activity

Drugs

Drug name Description
PALBOCICLIB CDK4/cyclin D1 inhibitor

Diseases

Disease Name
melanoma

Orthologs

Gene Organism
CDC28 S. cerevisiae
cdk-4 C. elegans
Cdk4 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000135446 CDK4 ENSG00000116478 HDAC1 H. sapiens SSL BioGRID 1.0 View
ENSG00000135446 CDK4 ENSG00000253729 PRKDC H. sapiens SSL BioGRID 1.0 View
ENSG00000135446 CDK4 ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000135446 CDK4 ENSG00000134086 VHL H. sapiens SSL BioGRID 1.0 View
ENSG00000171791 BCL2 ENSG00000135446 CDK4 H. sapiens SSL BioGRID 1.0 View
ENSG00000135446 CDK4 ENSG00000183765 CHEK2 H. sapiens SSL BioGRID 1.0 View
ENSG00000135446 CDK4 ENSG00000141736 ERBB2 H. sapiens SSL BioGRID 1.0 View
ENSG00000005339 CREBBP ENSG00000135446 CDK4 H. sapiens SDL Slorth 0.992603 View
ENSG00000100393 EP300 ENSG00000135446 CDK4 H. sapiens SDL Slorth 0.992516 View
ENSG00000132646 PCNA ENSG00000135446 CDK4 H. sapiens SDL Slorth 0.992279 View
ENSG00000012048 BRCA1 ENSG00000135446 CDK4 H. sapiens SDL Slorth 0.990839 View
ENSG00000091831 ESR1 ENSG00000135446 CDK4 H. sapiens SDL Slorth 0.985642 View
ENSG00000133703 KRAS ENSG00000135446 CDK4 H. sapiens SSL Slorth 0.981262 View
ENSG00000135446 CDK4 ENSG00000139687 RB1 H. sapiens SDL Slorth 0.98096 View
ENSG00000116478 HDAC1 ENSG00000135446 CDK4 H. sapiens SDL Slorth 0.980769 View
ENSG00000103275 UBE2I ENSG00000135446 CDK4 H. sapiens SDL Slorth 0.980488 View
ENSG00000113575 PPP2CA ENSG00000135446 CDK4 H. sapiens SSL Slorth 0.980025 View
ENSG00000135446 CDK4 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.979916 View
ENSG00000121022 COPS5 ENSG00000135446 CDK4 H. sapiens SSL Slorth 0.979843 View
ENSG00000109670 FBXW7 ENSG00000135446 CDK4 H. sapiens SSL Slorth 0.979703 View
ENSG00000135446 CDK4 ENSG00000167513 CDT1 H. sapiens SSL Slorth 0.979523 View
ENSG00000132383 RPA1 ENSG00000135446 CDK4 H. sapiens SSL Slorth 0.979481 View
ENSG00000101412 E2F1 ENSG00000135446 CDK4 H. sapiens SSL Slorth 0.979126 View
ENSG00000135446 CDK4 ENSG00000170365 SMAD1 H. sapiens SSL Slorth 0.979066 View
ENSG00000135446 CDK4 ENSG00000175387 SMAD2 H. sapiens SSL Slorth 0.978955 View
ENSG00000135446 CDK4 ENSG00000167513 CDT1 H. sapiens SDL Slorth 0.978889 View
ENSG00000135446 CDK4 ENSG00000145604 SKP2 H. sapiens SSL Slorth 0.978551 View
ENSG00000135446 CDK4 ENSG00000184900 SUMO3 H. sapiens SSL Slorth 0.978527 View
ENSG00000135446 CDK4 ENSG00000150991 UBC H. sapiens SDL Slorth 0.978486 View
ENSG00000082701 GSK3B ENSG00000135446 CDK4 H. sapiens SSL Slorth 0.978334 View
ENSG00000135446 CDK4 ENSG00000149554 CHEK1 H. sapiens SSL Slorth 0.978326 View
ENSG00000135446 CDK4 ENSG00000141543 EIF4A3 H. sapiens SSL Slorth 0.978172 View
ENSG00000135446 CDK4 ENSG00000159692 CTBP1 H. sapiens SSL Slorth 0.97804 View
ENSG00000112592 TBP ENSG00000135446 CDK4 H. sapiens SSL Slorth 0.978007 View
ENSG00000130726 TRIM28 ENSG00000135446 CDK4 H. sapiens SSL Slorth 0.977877 View
ENSG00000135446 CDK4 ENSG00000197299 BLM H. sapiens SSL Slorth 0.977851 View
ENSG00000005339 CREBBP ENSG00000135446 CDK4 H. sapiens SSL Slorth 0.977795 View
ENSG00000112062 MAPK14 ENSG00000135446 CDK4 H. sapiens SSL Slorth 0.977773 View
ENSG00000135446 CDK4 ENSG00000172531 PPP1CA H. sapiens SSL Slorth 0.977761 View
ENSG00000103275 UBE2I ENSG00000135446 CDK4 H. sapiens SSL Slorth 0.977533 View