BRAF

ENSG00000157764 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
GO:0031267 small GTPase binding

Drugs

Drug name Description
DABRAFENIB Serine/threonine-protein kinase B-raf inhibitor
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SORAFENIB Serine/threonine-protein kinase RAF inhibitor
VEMURAFENIB Serine/threonine-protein kinase B-raf inhibitor

Diseases

Disease Name
melanoma
colorectal
papillary thyroid
borderline ovarian
NSCLC
cholangiocarcinoma
pilocytic astrocytoma
Spitzoid tumour
pancreas acinar carcinoma
melanocytic nevus
prostate
gastric

Orthologs

Gene Organism
lin-45 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000157764 BRAF ENSG00000168522 FNTA H. sapiens SSL BioGRID 1.0 View
ENSG00000157764 BRAF ENSG00000196591 HDAC2 H. sapiens SSL BioGRID 1.0 View
ENSG00000157764 BRAF ENSG00000169032 MAP2K1 H. sapiens SSL BioGRID 1.0 View
ENSG00000157764 BRAF ENSG00000100030 MAPK1 H. sapiens SSL BioGRID 1.0 View
ENSG00000157764 BRAF ENSG00000121879 PIK3CA H. sapiens SSL BioGRID 1.0 View
ENSG00000157764 BRAF ENSG00000134086 VHL H. sapiens SSL BioGRID 1.0 View
ENSG00000157764 BRAF ENSG00000139618 BRCA2 H. sapiens SSL BioGRID 1.0 View
ENSG00000157764 BRAF ENSG00000146648 EGFR H. sapiens SSL BioGRID 1.0 View
ENSG00000157764 BRAF ENSG00000066468 FGFR2 H. sapiens SSL BioGRID 1.0 View
ENSG00000012048 BRCA1 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.990686 View
ENSG00000005339 CREBBP ENSG00000157764 BRAF H. sapiens SDL Slorth 0.988627 View
ENSG00000100393 EP300 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.987463 View
ENSG00000150991 UBC ENSG00000157764 BRAF H. sapiens SDL Slorth 0.9873 View
ENSG00000116478 HDAC1 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.984791 View
ENSG00000136997 MYC ENSG00000157764 BRAF H. sapiens SDL Slorth 0.984601 View
ENSG00000142208 AKT1 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.982258 View
ENSG00000135446 CDK4 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.979916 View
ENSG00000149554 CHEK1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.979856 View
ENSG00000101412 E2F1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.979059 View
ENSG00000101266 CSNK2A1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.978663 View
ENSG00000005339 CREBBP ENSG00000157764 BRAF H. sapiens SSL Slorth 0.977978 View
ENSG00000121022 COPS5 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.97788 View
ENSG00000112592 TBP ENSG00000157764 BRAF H. sapiens SSL Slorth 0.977839 View
ENSG00000123374 CDK2 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.97772 View
ENSG00000103275 UBE2I ENSG00000157764 BRAF H. sapiens SSL Slorth 0.977562 View
ENSG00000141646 SMAD4 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.977401 View
ENSG00000116030 SUMO1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.97736 View
ENSG00000157764 BRAF ENSG00000175387 SMAD2 H. sapiens SSL Slorth 0.977306 View
ENSG00000012048 BRCA1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.977265 View
ENSG00000132646 PCNA ENSG00000157764 BRAF H. sapiens SDL Slorth 0.976894 View
ENSG00000140464 PML ENSG00000157764 BRAF H. sapiens SDL Slorth 0.976556 View
ENSG00000101266 CSNK2A1 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.976433 View
ENSG00000137693 YAP1 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.976433 View
ENSG00000136997 MYC ENSG00000157764 BRAF H. sapiens SSL Slorth 0.976197 View
ENSG00000109670 FBXW7 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.975886 View
ENSG00000104365 IKBKB ENSG00000157764 BRAF H. sapiens SDL Slorth 0.975545 View
ENSG00000102882 MAPK3 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.9755 View
ENSG00000157764 BRAF ENSG00000159692 CTBP1 H. sapiens SSL Slorth 0.975471 View
ENSG00000112062 MAPK14 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.975452 View
ENSG00000141736 ERBB2 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.975229 View