BRAF

ENSG00000157764 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
GO:0031267 small GTPase binding

Drugs

Drug name Description
DABRAFENIB Serine/threonine-protein kinase B-raf inhibitor
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SORAFENIB Serine/threonine-protein kinase RAF inhibitor
VEMURAFENIB Serine/threonine-protein kinase B-raf inhibitor

Diseases

Disease Name
melanoma
colorectal
papillary thyroid
borderline ovarian
NSCLC
cholangiocarcinoma
pilocytic astrocytoma
Spitzoid tumour
pancreas acinar carcinoma
melanocytic nevus
prostate
gastric

Orthologs

Gene Organism
lin-45 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000157764 BRAF ENSG00000183207 RUVBL2 H. sapiens SSL Slorth 0.970423 View
ENSG00000157764 BRAF ENSG00000167513 CDT1 H. sapiens SSL Slorth 0.970408 View
ENSG00000142208 AKT1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.970386 View
ENSG00000117399 CDC20 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.970315 View
ENSG00000121774 KHDRBS1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.970055 View
ENSG00000079134 THOC1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.970031 View
ENSG00000130939 UBE4B ENSG00000157764 BRAF H. sapiens SSL Slorth 0.970005 View
ENSG00000157764 BRAF ENSG00000189067 LITAF H. sapiens SDL Slorth 0.970001 View
ENSG00000157764 BRAF ENSG00000254087 LYN H. sapiens SSL Slorth 0.969908 View
ENSG00000113721 PDGFRB ENSG00000157764 BRAF H. sapiens SSL Slorth 0.969892 View
ENSG00000143106 PSMA5 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.969815 View
ENSG00000133703 KRAS ENSG00000157764 BRAF H. sapiens SSL Slorth 0.969681 View
ENSG00000157764 BRAF ENSG00000170365 SMAD1 H. sapiens SSL Slorth 0.969597 View
ENSG00000070756 PABPC1 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.969575 View
ENSG00000157764 BRAF ENSG00000163932 PRKCD H. sapiens SSL Slorth 0.969566 View
ENSG00000157764 BRAF ENSG00000183735 TBK1 H. sapiens SSL Slorth 0.969563 View
ENSG00000157764 BRAF ENSG00000169398 PTK2 H. sapiens SSL Slorth 0.969472 View
ENSG00000097007 ABL1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.969423 View
ENSG00000141510 TP53 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.969324 View
ENSG00000157764 BRAF ENSG00000160145 KALRN H. sapiens SDL Slorth 0.969319 View
ENSG00000102882 MAPK3 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.969303 View
ENSG00000157764 BRAF ENSG00000213949 ITGA1 H. sapiens SDL Slorth 0.969286 View
ENSG00000060069 CTDP1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.969227 View
ENSG00000157764 BRAF ENSG00000166851 PLK1 H. sapiens SSL Slorth 0.969192 View
ENSG00000132964 CDK8 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.969105 View
ENSG00000157764 BRAF ENSG00000185359 HGS H. sapiens SSL Slorth 0.969062 View
ENSG00000157764 BRAF ENSG00000204103 MAFB H. sapiens SDL Slorth 0.969048 View
ENSG00000103194 USP10 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.968943 View
ENSG00000110395 CBL ENSG00000157764 BRAF H. sapiens SSL Slorth 0.968936 View
ENSG00000157764 BRAF ENSG00000182866 LCK H. sapiens SSL Slorth 0.968868 View
ENSG00000112062 MAPK14 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.968789 View
ENSG00000091831 ESR1 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.968394 View
ENSG00000157764 BRAF ENSG00000185651 UBE2L3 H. sapiens SSL Slorth 0.968197 View
ENSG00000157764 BRAF ENSG00000169045 HNRNPH1 H. sapiens SSL Slorth 0.967847 View
ENSG00000157764 BRAF ENSG00000213923 CSNK1E H. sapiens SSL Slorth 0.96771 View
ENSG00000119048 UBE2B ENSG00000157764 BRAF H. sapiens SSL Slorth 0.967659 View
ENSG00000157764 BRAF ENSG00000165025 SYK H. sapiens SSL Slorth 0.967615 View
ENSG00000157764 BRAF ENSG00000165409 TSHR H. sapiens SDL Slorth 0.967573 View
ENSG00000100644 HIF1A ENSG00000157764 BRAF H. sapiens SDL Slorth 0.967484 View
ENSG00000082898 XPO1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.967465 View