BRAF

ENSG00000157764 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
GO:0031267 small GTPase binding

Drugs

Drug name Description
DABRAFENIB Serine/threonine-protein kinase B-raf inhibitor
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SORAFENIB Serine/threonine-protein kinase RAF inhibitor
VEMURAFENIB Serine/threonine-protein kinase B-raf inhibitor

Diseases

Disease Name
melanoma
colorectal
papillary thyroid
borderline ovarian
NSCLC
cholangiocarcinoma
pilocytic astrocytoma
Spitzoid tumour
pancreas acinar carcinoma
melanocytic nevus
prostate
gastric

Orthologs

Gene Organism
lin-45 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000055130 CUL1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.96267 View
ENSG00000157764 BRAF ENSG00000178999 AURKB H. sapiens SSL Slorth 0.962647 View
ENSG00000084676 NCOA1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.962546 View
ENSG00000103126 AXIN1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.96253 View
ENSG00000141480 ARRB2 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.962471 View
ENSG00000138376 BARD1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.962304 View
ENSG00000157764 BRAF ENSG00000158987 RAPGEF6 H. sapiens SDL Slorth 0.962296 View
ENSG00000108443 RPS6KB1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.962214 View
ENSG00000110330 BIRC2 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.962086 View
ENSG00000115942 ORC2 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.962035 View
ENSG00000113558 SKP1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.962001 View
ENSG00000140992 PDPK1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.96195 View
ENSG00000157764 BRAF ENSG00000157933 SKI H. sapiens SSL Slorth 0.961784 View
ENSG00000133101 CCNA1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.961759 View
ENSG00000157764 BRAF ENSG00000170027 YWHAG H. sapiens SSL Slorth 0.961736 View
ENSG00000148400 NOTCH1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.961608 View
ENSG00000157764 BRAF ENSG00000178568 ERBB4 H. sapiens SSL Slorth 0.961532 View
ENSG00000157764 BRAF ENSG00000196470 SIAH1 H. sapiens SSL Slorth 0.961251 View
ENSG00000157764 BRAF ENSG00000184470 TXNRD2 H. sapiens SDL Slorth 0.961175 View
ENSG00000070950 RAD18 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.961112 View
ENSG00000082701 GSK3B ENSG00000157764 BRAF H. sapiens SDL Slorth 0.961043 View
ENSG00000157764 BRAF ENSG00000178950 GAK H. sapiens SSL Slorth 0.961029 View
ENSG00000157764 BRAF ENSG00000188130 MAPK12 H. sapiens SDL Slorth 0.960856 View
ENSG00000157764 BRAF ENSG00000175197 DDIT3 H. sapiens SSL Slorth 0.960818 View
ENSG00000157764 BRAF ENSG00000182511 FES H. sapiens SDL Slorth 0.960733 View
ENSG00000136628 EPRS ENSG00000157764 BRAF H. sapiens SSL Slorth 0.960732 View
ENSG00000157764 BRAF ENSG00000168610 STAT3 H. sapiens SSL Slorth 0.960656 View
ENSG00000157764 BRAF ENSG00000197122 SRC H. sapiens SDL Slorth 0.960651 View
ENSG00000141480 ARRB2 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.960578 View
ENSG00000157764 BRAF ENSG00000164362 TERT H. sapiens SSL Slorth 0.960398 View
ENSG00000157764 BRAF ENSG00000175793 SFN H. sapiens SSL Slorth 0.960368 View
ENSG00000136875 PRPF4 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.96035 View
ENSG00000157764 BRAF ENSG00000158402 CDC25C H. sapiens SSL Slorth 0.960347 View
ENSG00000124181 PLCG1 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.960343 View
ENSG00000091831 ESR1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.960287 View
ENSG00000157764 BRAF ENSG00000160691 SHC1 H. sapiens SSL Slorth 0.960177 View
ENSG00000157764 BRAF ENSG00000206181 TCEB3B H. sapiens SDL Slorth 0.960173 View
ENSG00000137154 RPS6 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.960159 View
ENSG00000128908 INO80 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.959996 View
ENSG00000070010 UFD1L ENSG00000157764 BRAF H. sapiens SSL Slorth 0.959876 View