BRAF

ENSG00000157764 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
GO:0031267 small GTPase binding

Drugs

Drug name Description
DABRAFENIB Serine/threonine-protein kinase B-raf inhibitor
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SORAFENIB Serine/threonine-protein kinase RAF inhibitor
VEMURAFENIB Serine/threonine-protein kinase B-raf inhibitor

Diseases

Disease Name
melanoma
colorectal
papillary thyroid
borderline ovarian
NSCLC
cholangiocarcinoma
pilocytic astrocytoma
Spitzoid tumour
pancreas acinar carcinoma
melanocytic nevus
prostate
gastric

Orthologs

Gene Organism
lin-45 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000058729 RIOK2 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.950198 View
ENSG00000132326 PER2 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.95008 View
ENSG00000110330 BIRC2 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.949976 View
ENSG00000157764 BRAF ENSG00000170312 CDK1 H. sapiens SSL Slorth 0.949758 View
ENSG00000157764 BRAF ENSG00000177981 ASB8 H. sapiens SDL Slorth 0.949648 View
ENSG00000157764 BRAF ENSG00000163932 PRKCD H. sapiens SDL Slorth 0.949555 View
ENSG00000125952 MAX ENSG00000157764 BRAF H. sapiens SSL Slorth 0.949415 View
ENSG00000149554 CHEK1 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.949397 View
ENSG00000109971 HSPA8 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.949222 View
ENSG00000157764 BRAF ENSG00000170606 HSPA4 H. sapiens SSL Slorth 0.949107 View
ENSG00000157764 BRAF ENSG00000162231 NXF1 H. sapiens SSL Slorth 0.949099 View
ENSG00000157764 BRAF ENSG00000163466 ARPC2 H. sapiens SSL Slorth 0.94907 View
ENSG00000101665 SMAD7 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.949059 View
ENSG00000117713 ARID1A ENSG00000157764 BRAF H. sapiens SSL Slorth 0.948966 View
ENSG00000138069 RAB1A ENSG00000157764 BRAF H. sapiens SSL Slorth 0.948954 View
ENSG00000108840 HDAC5 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.948885 View
ENSG00000100644 HIF1A ENSG00000157764 BRAF H. sapiens SSL Slorth 0.948877 View
ENSG00000157764 BRAF ENSG00000163558 PRKCI H. sapiens SSL Slorth 0.948811 View
ENSG00000141646 SMAD4 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.948808 View
ENSG00000004897 CDC27 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.948616 View
ENSG00000154473 BUB3 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.948456 View
ENSG00000117748 RPA2 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.948366 View
ENSG00000105173 CCNE1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.948362 View
ENSG00000157764 BRAF ENSG00000188021 UBQLN2 H. sapiens SSL Slorth 0.948345 View
ENSG00000135624 CCT7 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.948125 View
ENSG00000157764 BRAF ENSG00000177189 RPS6KA3 H. sapiens SDL Slorth 0.947961 View
ENSG00000047315 POLR2B ENSG00000157764 BRAF H. sapiens SSL Slorth 0.94782 View
ENSG00000106588 PSMA2 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.947766 View
ENSG00000145604 SKP2 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.947755 View
ENSG00000157764 BRAF ENSG00000166226 CCT2 H. sapiens SSL Slorth 0.947707 View
ENSG00000106462 EZH2 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.947701 View
ENSG00000157764 BRAF ENSG00000177606 JUN H. sapiens SDL Slorth 0.947525 View
ENSG00000141736 ERBB2 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.947515 View
ENSG00000157764 BRAF ENSG00000172053 QARS H. sapiens SSL Slorth 0.947267 View
ENSG00000109320 NFKB1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.947236 View
ENSG00000157764 BRAF ENSG00000198909 MAP3K3 H. sapiens SSL Slorth 0.947218 View
ENSG00000123124 WWP1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.947214 View
ENSG00000085832 EPS15 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.947134 View
ENSG00000157764 BRAF ENSG00000178607 ERN1 H. sapiens SSL Slorth 0.947122 View
ENSG00000071051 NCK2 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.946838 View