BRAF

ENSG00000157764 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
GO:0031267 small GTPase binding

Drugs

Drug name Description
DABRAFENIB Serine/threonine-protein kinase B-raf inhibitor
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SORAFENIB Serine/threonine-protein kinase RAF inhibitor
VEMURAFENIB Serine/threonine-protein kinase B-raf inhibitor

Diseases

Disease Name
melanoma
colorectal
papillary thyroid
borderline ovarian
NSCLC
cholangiocarcinoma
pilocytic astrocytoma
Spitzoid tumour
pancreas acinar carcinoma
melanocytic nevus
prostate
gastric

Orthologs

Gene Organism
lin-45 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000079102 RUNX1T1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.953119 View
ENSG00000077097 TOP2B ENSG00000157764 BRAF H. sapiens SDL Slorth 0.952963 View
ENSG00000157764 BRAF ENSG00000173404 INSM1 H. sapiens SDL Slorth 0.952726 View
ENSG00000157764 BRAF ENSG00000169967 MAP3K2 H. sapiens SSL Slorth 0.952712 View
ENSG00000129691 ASH2L ENSG00000157764 BRAF H. sapiens SSL Slorth 0.952591 View
ENSG00000157764 BRAF ENSG00000162302 RPS6KA4 H. sapiens SDL Slorth 0.952507 View
ENSG00000136238 RAC1 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.95247 View
ENSG00000137486 ARRB1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.952395 View
ENSG00000067560 RHOA ENSG00000157764 BRAF H. sapiens SSL Slorth 0.952264 View
ENSG00000067560 RHOA ENSG00000157764 BRAF H. sapiens SDL Slorth 0.952254 View
ENSG00000157106 SMG1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.952253 View
ENSG00000157764 BRAF ENSG00000164305 CASP3 H. sapiens SSL Slorth 0.952172 View
ENSG00000114062 UBE3A ENSG00000157764 BRAF H. sapiens SSL Slorth 0.951981 View
ENSG00000157764 BRAF ENSG00000170248 PDCD6IP H. sapiens SSL Slorth 0.951837 View
ENSG00000075624 ACTB ENSG00000157764 BRAF H. sapiens SSL Slorth 0.951833 View
ENSG00000076242 MLH1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.951821 View
ENSG00000157764 BRAF ENSG00000185022 MAFF H. sapiens SDL Slorth 0.951798 View
ENSG00000132341 RAN ENSG00000157764 BRAF H. sapiens SSL Slorth 0.951778 View
ENSG00000134982 APC ENSG00000157764 BRAF H. sapiens SSL Slorth 0.951736 View
ENSG00000157764 BRAF ENSG00000184675 AMER1 H. sapiens SDL Slorth 0.951735 View
ENSG00000096968 JAK2 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.951716 View
ENSG00000157764 BRAF ENSG00000160789 LMNA H. sapiens SDL Slorth 0.951675 View
ENSG00000036257 CUL3 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.951565 View
ENSG00000157764 BRAF ENSG00000180370 PAK2 H. sapiens SSL Slorth 0.951525 View
ENSG00000103126 AXIN1 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.951422 View
ENSG00000157764 BRAF ENSG00000186575 NF2 H. sapiens SSL Slorth 0.95134 View
ENSG00000136238 RAC1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.95133 View
ENSG00000157764 BRAF ENSG00000172977 KAT5 H. sapiens SSL Slorth 0.951259 View
ENSG00000130699 TAF4 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.951237 View
ENSG00000157764 BRAF ENSG00000188486 H2AFX H. sapiens SSL Slorth 0.951149 View
ENSG00000157764 BRAF ENSG00000183791 TCEB3C H. sapiens SDL Slorth 0.951047 View
ENSG00000157764 BRAF ENSG00000175634 RPS6KB2 H. sapiens SDL Slorth 0.950898 View
ENSG00000157764 BRAF ENSG00000254772 EEF1G H. sapiens SSL Slorth 0.95089 View
ENSG00000157764 BRAF ENSG00000253729 PRKDC H. sapiens SSL Slorth 0.950809 View
ENSG00000157764 BRAF ENSG00000173039 RELA H. sapiens SSL Slorth 0.950724 View
ENSG00000093009 CDC45 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.950682 View
ENSG00000157764 BRAF ENSG00000198087 CD2AP H. sapiens SSL Slorth 0.950544 View
ENSG00000157764 BRAF ENSG00000168421 RHOH H. sapiens SDL Slorth 0.950517 View
ENSG00000129559 NEDD8 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.950299 View
ENSG00000001167 NFYA ENSG00000157764 BRAF H. sapiens SSL Slorth 0.95026 View