BRAF

ENSG00000157764 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
GO:0031267 small GTPase binding

Drugs

Drug name Description
DABRAFENIB Serine/threonine-protein kinase B-raf inhibitor
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SORAFENIB Serine/threonine-protein kinase RAF inhibitor
VEMURAFENIB Serine/threonine-protein kinase B-raf inhibitor

Diseases

Disease Name
melanoma
colorectal
papillary thyroid
borderline ovarian
NSCLC
cholangiocarcinoma
pilocytic astrocytoma
Spitzoid tumour
pancreas acinar carcinoma
melanocytic nevus
prostate
gastric

Orthologs

Gene Organism
lin-45 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000124181 PLCG1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.975209 View
ENSG00000103275 UBE2I ENSG00000157764 BRAF H. sapiens SDL Slorth 0.975063 View
ENSG00000113575 PPP2CA ENSG00000157764 BRAF H. sapiens SSL Slorth 0.975008 View
ENSG00000096717 SIRT1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.97481 View
ENSG00000146648 EGFR ENSG00000157764 BRAF H. sapiens SDL Slorth 0.974748 View
ENSG00000137693 YAP1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.974733 View
ENSG00000157764 BRAF ENSG00000197299 BLM H. sapiens SSL Slorth 0.974705 View
ENSG00000111276 CDKN1B ENSG00000157764 BRAF H. sapiens SSL Slorth 0.974464 View
ENSG00000157764 BRAF ENSG00000177889 UBE2N H. sapiens SSL Slorth 0.974418 View
ENSG00000157764 BRAF ENSG00000184900 SUMO3 H. sapiens SSL Slorth 0.973994 View
ENSG00000122406 RPL5 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.973987 View
ENSG00000111276 CDKN1B ENSG00000157764 BRAF H. sapiens SDL Slorth 0.973747 View
ENSG00000082701 GSK3B ENSG00000157764 BRAF H. sapiens SSL Slorth 0.973689 View
ENSG00000157764 BRAF ENSG00000213341 CHUK H. sapiens SSL Slorth 0.973613 View
ENSG00000123374 CDK2 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.973561 View
ENSG00000010810 FYN ENSG00000157764 BRAF H. sapiens SSL Slorth 0.973412 View
ENSG00000157764 BRAF ENSG00000196419 XRCC6 H. sapiens SSL Slorth 0.973261 View
ENSG00000135486 HNRNPA1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.973186 View
ENSG00000157764 BRAF ENSG00000167986 DDB1 H. sapiens SSL Slorth 0.972756 View
ENSG00000109906 ZBTB16 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.972706 View
ENSG00000157764 BRAF ENSG00000181163 NPM1 H. sapiens SSL Slorth 0.972598 View
ENSG00000131759 RARA ENSG00000157764 BRAF H. sapiens SSL Slorth 0.972346 View
ENSG00000139687 RB1 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.972273 View
ENSG00000113558 SKP1 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.971987 View
ENSG00000157764 BRAF ENSG00000170345 FOS H. sapiens SSL Slorth 0.971819 View
ENSG00000061273 HDAC7 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.971809 View
ENSG00000116016 EPAS1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.971778 View
ENSG00000136807 CDK9 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.971637 View
ENSG00000124762 CDKN1A ENSG00000157764 BRAF H. sapiens SSL Slorth 0.971602 View
ENSG00000124762 CDKN1A ENSG00000157764 BRAF H. sapiens SDL Slorth 0.971573 View
ENSG00000100030 MAPK1 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.971474 View
ENSG00000157764 BRAF ENSG00000183684 ALYREF H. sapiens SSL Slorth 0.971356 View
ENSG00000157764 BRAF ENSG00000159216 RUNX1 H. sapiens SSL Slorth 0.971351 View
ENSG00000069869 NEDD4 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.97133 View
ENSG00000157764 BRAF ENSG00000187555 USP7 H. sapiens SSL Slorth 0.971254 View
ENSG00000134308 YWHAQ ENSG00000157764 BRAF H. sapiens SDL Slorth 0.971214 View
ENSG00000065559 MAP2K4 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.971068 View
ENSG00000157764 BRAF ENSG00000165392 WRN H. sapiens SSL Slorth 0.970637 View
ENSG00000157764 BRAF ENSG00000186868 MAPT H. sapiens SSL Slorth 0.9706 View
ENSG00000101966 XIAP ENSG00000157764 BRAF H. sapiens SSL Slorth 0.970508 View