EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000157764 BRAF ENSG00000146648 EGFR H. sapiens SSL BioGRID 1.0 View
ENSG00000146648 EGFR ENSG00000133703 KRAS H. sapiens SSL BioGRID 1.0 View
ENSG00000146648 EGFR ENSG00000141510 TP53 H. sapiens SSL BioGRID 1.0 View
ENSG00000146648 EGFR ENSG00000185359 HGS H. sapiens SDL Slorth 0.992397 View
ENSG00000146648 EGFR ENSG00000160271 RALGDS H. sapiens SDL Slorth 0.989756 View
ENSG00000146648 EGFR ENSG00000242173 ARHGDIG H. sapiens SDL Slorth 0.989462 View
ENSG00000146648 EGFR ENSG00000171435 KSR2 H. sapiens SDL Slorth 0.989432 View
ENSG00000146648 EGFR ENSG00000189079 ARID2 H. sapiens SDL Slorth 0.989011 View
ENSG00000146648 EGFR ENSG00000178188 SH2B1 H. sapiens SDL Slorth 0.988922 View
ENSG00000146648 EGFR ENSG00000160293 VAV2 H. sapiens SDL Slorth 0.988912 View
ENSG00000146648 EGFR ENSG00000165506 DNAAF2 H. sapiens SDL Slorth 0.988857 View
ENSG00000146648 EGFR ENSG00000214102 WEE2 H. sapiens SDL Slorth 0.988771 View
ENSG00000146648 EGFR ENSG00000196923 PDLIM7 H. sapiens SDL Slorth 0.988728 View
ENSG00000146648 EGFR ENSG00000187098 MITF H. sapiens SDL Slorth 0.988688 View
ENSG00000146648 EGFR ENSG00000153071 DAB2 H. sapiens SDL Slorth 0.988617 View
ENSG00000146648 EGFR ENSG00000164056 SPRY1 H. sapiens SDL Slorth 0.988458 View
ENSG00000146648 EGFR ENSG00000184557 SOCS3 H. sapiens SDL Slorth 0.988381 View
ENSG00000146648 EGFR ENSG00000162434 JAK1 H. sapiens SDL Slorth 0.988344 View
ENSG00000146648 EGFR ENSG00000181788 SIAH2 H. sapiens SDL Slorth 0.988256 View
ENSG00000146648 EGFR ENSG00000170248 PDCD6IP H. sapiens SDL Slorth 0.988176 View
ENSG00000146648 EGFR ENSG00000183763 TRAIP H. sapiens SDL Slorth 0.988132 View
ENSG00000146648 EGFR ENSG00000205726 ITSN1 H. sapiens SDL Slorth 0.988126 View
ENSG00000146648 EGFR ENSG00000178691 SUZ12 H. sapiens SDL Slorth 0.988105 View
ENSG00000146648 EGFR ENSG00000175832 ETV4 H. sapiens SDL Slorth 0.987965 View
ENSG00000146648 EGFR ENSG00000169045 HNRNPH1 H. sapiens SDL Slorth 0.987907 View
ENSG00000146648 EGFR ENSG00000269858 EGLN2 H. sapiens SDL Slorth 0.987766 View
ENSG00000146648 EGFR ENSG00000158186 MRAS H. sapiens SDL Slorth 0.98774 View
ENSG00000146648 EGFR ENSG00000157077 ZFYVE9 H. sapiens SDL Slorth 0.987375 View
ENSG00000063245 EPN1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.987375 View
ENSG00000146648 EGFR ENSG00000168283 BMI1 H. sapiens SDL Slorth 0.987322 View
ENSG00000146648 EGFR ENSG00000157557 ETS2 H. sapiens SDL Slorth 0.987268 View
ENSG00000146648 EGFR ENSG00000169891 REPS2 H. sapiens SDL Slorth 0.987256 View
ENSG00000146648 EGFR ENSG00000168439 STIP1 H. sapiens SDL Slorth 0.987205 View
ENSG00000146648 EGFR ENSG00000173542 MOB1B H. sapiens SDL Slorth 0.987186 View
ENSG00000146648 EGFR ENSG00000167548 KMT2D H. sapiens SDL Slorth 0.987157 View
ENSG00000146648 EGFR ENSG00000163629 PTPN13 H. sapiens SDL Slorth 0.987079 View
ENSG00000146648 EGFR ENSG00000158022 TRIM63 H. sapiens SDL Slorth 0.987012 View
ENSG00000146648 EGFR ENSG00000174791 RIN1 H. sapiens SDL Slorth 0.986883 View
ENSG00000146648 EGFR ENSG00000175745 NR2F1 H. sapiens SDL Slorth 0.986851 View
ENSG00000146648 EGFR ENSG00000157514 TSC22D3 H. sapiens SDL Slorth 0.986758 View