EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000146648 EGFR ENSG00000204388 HSPA1B H. sapiens SDL Slorth 0.983337 View
ENSG00000146648 EGFR ENSG00000198286 CARD11 H. sapiens SDL Slorth 0.983333 View
ENSG00000090520 DNAJB11 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983329 View
ENSG00000079432 CIC ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983304 View
ENSG00000145916 RMND5B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983252 View
ENSG00000146648 EGFR ENSG00000187840 EIF4EBP1 H. sapiens SDL Slorth 0.983231 View
ENSG00000146648 EGFR ENSG00000182578 CSF1R H. sapiens SDL Slorth 0.983176 View
ENSG00000146648 EGFR ENSG00000176986 SEC24C H. sapiens SDL Slorth 0.983139 View
ENSG00000146648 EGFR ENSG00000147443 DOK2 H. sapiens SDL Slorth 0.983118 View
ENSG00000132849 PATJ ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983117 View
ENSG00000100320 RBFOX2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983116 View
ENSG00000137171 KLC4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983109 View
ENSG00000146648 EGFR ENSG00000169813 HNRNPF H. sapiens SDL Slorth 0.983107 View
ENSG00000139219 COL2A1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983096 View
ENSG00000102967 DHODH ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983089 View
ENSG00000146648 EGFR ENSG00000221829 FANCG H. sapiens SDL Slorth 0.983073 View
ENSG00000066455 GOLGA5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983053 View
ENSG00000077943 ITGA8 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983044 View
ENSG00000100503 NIN ENSG00000146648 EGFR H. sapiens SDL Slorth 0.983015 View
ENSG00000105290 APLP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982995 View
ENSG00000146648 EGFR ENSG00000187522 HSPA14 H. sapiens SDL Slorth 0.982924 View
ENSG00000143776 CDC42BPA ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982922 View
ENSG00000015285 WAS ENSG00000146648 EGFR H. sapiens SDL Slorth 0.98292 View
ENSG00000129245 FXR2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982891 View
ENSG00000146648 EGFR ENSG00000198176 TFDP1 H. sapiens SDL Slorth 0.982888 View
ENSG00000146648 EGFR ENSG00000163902 RPN1 H. sapiens SDL Slorth 0.982844 View
ENSG00000111859 NEDD9 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982837 View
ENSG00000055609 KMT2C ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982808 View
ENSG00000146094 DOK3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982803 View
ENSG00000129204 USP6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982793 View
ENSG00000073350 LLGL2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982738 View
ENSG00000139116 KIF21A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982718 View
ENSG00000066923 STAG3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982709 View
ENSG00000144488 ESPNL ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982709 View
ENSG00000100982 PCIF1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982708 View
ENSG00000143420 ENSA ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982705 View
ENSG00000070718 AP3M2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982692 View
ENSG00000096968 JAK2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982686 View
ENSG00000146648 EGFR ENSG00000182606 TRAK1 H. sapiens SDL Slorth 0.982668 View
ENSG00000146648 EGFR ENSG00000164305 CASP3 H. sapiens SDL Slorth 0.982653 View