EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000079156 OSBPL6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.984887 View
ENSG00000067992 PDK3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.984877 View
ENSG00000100239 PPP6R2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.984859 View
ENSG00000146648 EGFR ENSG00000155090 KLF10 H. sapiens SDL Slorth 0.984858 View
ENSG00000136014 USP44 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.984848 View
ENSG00000106346 USP42 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.984825 View
ENSG00000067829 IDH3G ENSG00000146648 EGFR H. sapiens SDL Slorth 0.984825 View
ENSG00000146648 EGFR ENSG00000175592 FOSL1 H. sapiens SDL Slorth 0.984816 View
ENSG00000130703 OSBPL2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.984803 View
ENSG00000146648 EGFR ENSG00000183454 GRIN2A H. sapiens SDL Slorth 0.984782 View
ENSG00000085449 WDFY1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.984731 View
ENSG00000135597 REPS1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.98472 View
ENSG00000077935 SMC1B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.98472 View
ENSG00000086619 ERO1B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.98472 View
ENSG00000004848 ARX ENSG00000146648 EGFR H. sapiens SDL Slorth 0.98472 View
ENSG00000146648 EGFR ENSG00000172531 PPP1CA H. sapiens SDL Slorth 0.984702 View
ENSG00000102996 MMP15 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.984681 View
ENSG00000100372 SLC25A17 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.984667 View
ENSG00000077380 DYNC1I2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.984667 View
ENSG00000146648 EGFR ENSG00000155849 ELMO1 H. sapiens SDL Slorth 0.984621 View
ENSG00000146648 EGFR ENSG00000205339 IPO7 H. sapiens SDL Slorth 0.98461 View
ENSG00000146648 EGFR ENSG00000156299 TIAM1 H. sapiens SDL Slorth 0.984593 View
ENSG00000145358 DDIT4L ENSG00000146648 EGFR H. sapiens SDL Slorth 0.984586 View
ENSG00000110048 OSBP ENSG00000146648 EGFR H. sapiens SDL Slorth 0.984574 View
ENSG00000146648 EGFR ENSG00000197579 TOPORS H. sapiens SDL Slorth 0.984558 View
ENSG00000146648 EGFR ENSG00000177565 TBL1XR1 H. sapiens SDL Slorth 0.984484 View
ENSG00000146648 EGFR ENSG00000176444 CLK2 H. sapiens SDL Slorth 0.984482 View
ENSG00000146648 EGFR ENSG00000173757 STAT5B H. sapiens SDL Slorth 0.984478 View
ENSG00000146648 EGFR ENSG00000198959 TGM2 H. sapiens SDL Slorth 0.984414 View
ENSG00000146648 EGFR ENSG00000204842 ATXN2 H. sapiens SDL Slorth 0.984383 View
ENSG00000138829 FBN2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.984372 View
ENSG00000134871 COL4A2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.984372 View
ENSG00000146648 EGFR ENSG00000164050 PLXNB1 H. sapiens SDL Slorth 0.984335 View
ENSG00000146648 EGFR ENSG00000147162 OGT H. sapiens SDL Slorth 0.984318 View
ENSG00000146648 EGFR ENSG00000165416 SUGT1 H. sapiens SDL Slorth 0.98431 View
ENSG00000146648 EGFR ENSG00000213066 FGFR1OP H. sapiens SDL Slorth 0.984305 View
ENSG00000146648 EGFR ENSG00000172115 CYCS H. sapiens SDL Slorth 0.98426 View
ENSG00000146648 EGFR ENSG00000165806 CASP7 H. sapiens SDL Slorth 0.984254 View
ENSG00000119403 PHF19 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.984214 View
ENSG00000146648 EGFR ENSG00000198001 IRAK4 H. sapiens SDL Slorth 0.984207 View