EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000146648 EGFR ENSG00000197943 PLCG2 H. sapiens SDL Slorth 0.986713 View
ENSG00000146648 EGFR ENSG00000162924 REL H. sapiens SDL Slorth 0.98667 View
ENSG00000146648 EGFR ENSG00000155508 CNOT8 H. sapiens SDL Slorth 0.986609 View
ENSG00000138448 ITGAV ENSG00000146648 EGFR H. sapiens SDL Slorth 0.986572 View
ENSG00000146648 EGFR ENSG00000244405 ETV5 H. sapiens SDL Slorth 0.986557 View
ENSG00000146648 EGFR ENSG00000175220 ARHGAP1 H. sapiens SDL Slorth 0.986433 View
ENSG00000146648 EGFR ENSG00000154001 PPP2R5E H. sapiens SDL Slorth 0.986432 View
ENSG00000146648 EGFR ENSG00000154380 ENAH H. sapiens SDL Slorth 0.98633 View
ENSG00000146648 EGFR ENSG00000187239 FNBP1 H. sapiens SDL Slorth 0.986216 View
ENSG00000146648 EGFR ENSG00000159593 NAE1 H. sapiens SDL Slorth 0.986083 View
ENSG00000146648 EGFR ENSG00000156052 GNAQ H. sapiens SDL Slorth 0.986015 View
ENSG00000146648 EGFR ENSG00000158987 RAPGEF6 H. sapiens SDL Slorth 0.986003 View
ENSG00000080561 MID2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.985779 View
ENSG00000274176 CNOT3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.985779 View
ENSG00000064933 PMS1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.985761 View
ENSG00000146648 EGFR ENSG00000198719 DLL1 H. sapiens SDL Slorth 0.985733 View
ENSG00000146648 EGFR ENSG00000156709 AIFM1 H. sapiens SDL Slorth 0.985714 View
ENSG00000146648 EGFR ENSG00000198901 PRC1 H. sapiens SDL Slorth 0.985675 View
ENSG00000146648 EGFR ENSG00000171150 SOCS5 H. sapiens SDL Slorth 0.985671 View
ENSG00000146648 EGFR ENSG00000245848 CEBPA H. sapiens SDL Slorth 0.985634 View
ENSG00000146648 EGFR ENSG00000169554 ZEB2 H. sapiens SDL Slorth 0.985631 View
ENSG00000146648 EGFR ENSG00000196914 ARHGEF12 H. sapiens SDL Slorth 0.985619 View
ENSG00000127580 WDR24 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.985537 View
ENSG00000146648 EGFR ENSG00000198373 WWP2 H. sapiens SDL Slorth 0.985512 View
ENSG00000146648 EGFR ENSG00000163660 CCNL1 H. sapiens SDL Slorth 0.985418 View
ENSG00000146648 EGFR ENSG00000156475 PPP2R2B H. sapiens SDL Slorth 0.985408 View
ENSG00000146648 EGFR ENSG00000172059 KLF11 H. sapiens SDL Slorth 0.985374 View
ENSG00000146648 EGFR ENSG00000178562 CD28 H. sapiens SDL Slorth 0.985329 View
ENSG00000146648 EGFR ENSG00000158169 FANCC H. sapiens SDL Slorth 0.985231 View
ENSG00000146648 EGFR ENSG00000157873 TNFRSF14 H. sapiens SDL Slorth 0.985172 View
ENSG00000023318 ERP44 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.985128 View
ENSG00000146648 EGFR ENSG00000214517 PPME1 H. sapiens SDL Slorth 0.985124 View
ENSG00000146648 EGFR ENSG00000176105 YES1 H. sapiens SDL Slorth 0.985081 View
ENSG00000146648 EGFR ENSG00000154229 PRKCA H. sapiens SDL Slorth 0.985053 View
ENSG00000137073 UBAP2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.984985 View
ENSG00000146648 EGFR ENSG00000167004 PDIA3 H. sapiens SDL Slorth 0.984953 View
ENSG00000146648 EGFR ENSG00000183814 LIN9 H. sapiens SDL Slorth 0.984941 View
ENSG00000099785 MARCH2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.98494 View
ENSG00000102683 SGCG ENSG00000146648 EGFR H. sapiens SDL Slorth 0.98494 View
ENSG00000146648 EGFR ENSG00000147050 KDM6A H. sapiens SDL Slorth 0.984912 View