EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000146648 EGFR ENSG00000184428 TOP1MT H. sapiens SSL Slorth 0.760202 View
ENSG00000146648 EGFR ENSG00000204301 NOTCH4 H. sapiens SSL Slorth 0.760182 View
ENSG00000146648 EGFR ENSG00000166887 VPS39 H. sapiens SSL Slorth 0.759657 View
ENSG00000146648 EGFR ENSG00000149182 ARFGAP2 H. sapiens SSL Slorth 0.75912 View
ENSG00000146648 EGFR ENSG00000179348 GATA2 H. sapiens SSL Slorth 0.759087 View
ENSG00000146648 EGFR ENSG00000204220 PFDN6 H. sapiens SSL Slorth 0.759038 View
ENSG00000146648 EGFR ENSG00000261796 ISY1-RAB43 H. sapiens SSL Slorth 0.758896 View
ENSG00000146648 EGFR ENSG00000171148 TADA3 H. sapiens SSL Slorth 0.758809 View
ENSG00000146648 EGFR ENSG00000204389 HSPA1A H. sapiens SSL Slorth 0.758581 View
ENSG00000146648 EGFR ENSG00000184110 EIF3C H. sapiens SSL Slorth 0.757249 View
ENSG00000146648 EGFR ENSG00000147536 GINS4 H. sapiens SSL Slorth 0.75663 View
ENSG00000146648 EGFR ENSG00000156802 ATAD2 H. sapiens SSL Slorth 0.755838 View
ENSG00000146648 EGFR ENSG00000188130 MAPK12 H. sapiens SSL Slorth 0.755762 View
ENSG00000146648 EGFR ENSG00000175305 CCNE2 H. sapiens SSL Slorth 0.754943 View
ENSG00000146648 EGFR ENSG00000148835 TAF5 H. sapiens SSL Slorth 0.754818 View
ENSG00000146648 EGFR ENSG00000171763 SPATA5L1 H. sapiens SSL Slorth 0.754578 View
ENSG00000146648 EGFR ENSG00000149930 TAOK2 H. sapiens SSL Slorth 0.754564 View
ENSG00000146648 EGFR ENSG00000198467 TPM2 H. sapiens SSL Slorth 0.753393 View
ENSG00000146648 EGFR ENSG00000159200 RCAN1 H. sapiens SSL Slorth 0.753 View
ENSG00000146648 EGFR ENSG00000158545 ZC3H18 H. sapiens SSL Slorth 0.752619 View
ENSG00000146648 EGFR ENSG00000154059 IMPACT H. sapiens SSL Slorth 0.752208 View
ENSG00000146648 EGFR ENSG00000172939 OXSR1 H. sapiens SSL Slorth 0.751826 View
ENSG00000146648 EGFR ENSG00000165684 SNAPC4 H. sapiens SSL Slorth 0.751576 View
ENSG00000146648 EGFR ENSG00000170855 TRIAP1 H. sapiens SSL Slorth 0.751434 View
ENSG00000146648 EGFR ENSG00000150779 TIMM8B H. sapiens SSL Slorth 0.75017 View