EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000066027 PPP2R5A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.98262 View
ENSG00000115221 ITGB6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982566 View
ENSG00000021574 SPAST ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982554 View
ENSG00000127329 PTPRB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982551 View
ENSG00000087995 METTL2A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982544 View
ENSG00000104388 RAB2A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.98254 View
ENSG00000146648 EGFR ENSG00000170242 USP47 H. sapiens SDL Slorth 0.982504 View
ENSG00000100234 TIMP3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982504 View
ENSG00000099364 FBXL19 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982487 View
ENSG00000143756 FBXO28 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982487 View
ENSG00000072422 RHOBTB1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982431 View
ENSG00000008853 RHOBTB2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982431 View
ENSG00000146648 EGFR ENSG00000177733 HNRNPA0 H. sapiens SDL Slorth 0.982395 View
ENSG00000145734 BDP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982394 View
ENSG00000142751 GPN2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982394 View
ENSG00000132466 ANKRD17 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982386 View
ENSG00000146648 EGFR ENSG00000166483 WEE1 H. sapiens SDL Slorth 0.982385 View
ENSG00000120539 MASTL ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982362 View
ENSG00000101365 IDH3B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982358 View
ENSG00000101972 STAG2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982309 View
ENSG00000140022 STON2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982307 View
ENSG00000146648 EGFR ENSG00000161270 NPHS1 H. sapiens SDL Slorth 0.982282 View
ENSG00000107872 FBXL15 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982262 View
ENSG00000146648 EGFR ENSG00000185697 MYBL1 H. sapiens SDL Slorth 0.982261 View
ENSG00000117410 ATP6V0B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982256 View
ENSG00000146648 EGFR ENSG00000151422 FER H. sapiens SDL Slorth 0.98223 View
ENSG00000029639 TFB1M ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982228 View
ENSG00000146648 EGFR ENSG00000173209 AHSA2 H. sapiens SDL Slorth 0.982224 View
ENSG00000143847 PPFIA4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982196 View
ENSG00000146648 EGFR ENSG00000169047 IRS1 H. sapiens SDL Slorth 0.98219 View
ENSG00000118508 RAB32 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982175 View
ENSG00000116266 STXBP3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982122 View
ENSG00000103222 ABCC1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982111 View
ENSG00000146648 EGFR ENSG00000198399 ITSN2 H. sapiens SDL Slorth 0.982098 View
ENSG00000146648 EGFR ENSG00000159720 ATP6V0D1 H. sapiens SDL Slorth 0.982081 View
ENSG00000146648 EGFR ENSG00000164362 TERT H. sapiens SDL Slorth 0.982068 View
ENSG00000146648 EGFR ENSG00000150995 ITPR1 H. sapiens SDL Slorth 0.982062 View
ENSG00000131941 RHPN2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982036 View
ENSG00000136143 SUCLA2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982026 View
ENSG00000146648 EGFR ENSG00000152795 HNRNPDL H. sapiens SDL Slorth 0.982019 View