EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000140332 TLE3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980218 View
ENSG00000138395 CDK15 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980214 View
ENSG00000146648 EGFR ENSG00000168209 DDIT4 H. sapiens SDL Slorth 0.980187 View
ENSG00000108924 HLF ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980163 View
ENSG00000144283 PKP4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980144 View
ENSG00000065029 ZNF76 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980129 View
ENSG00000129170 CSRP3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980109 View
ENSG00000011454 RABGAP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980091 View
ENSG00000139631 CSAD ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980061 View
ENSG00000144644 GADL1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980061 View
ENSG00000145743 FBXL17 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980061 View
ENSG00000112234 FBXL4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980061 View
ENSG00000146648 EGFR ENSG00000160948 VPS28 H. sapiens SDL Slorth 0.980052 View
ENSG00000146648 EGFR ENSG00000155366 RHOC H. sapiens SDL Slorth 0.980049 View
ENSG00000146648 EGFR ENSG00000171848 RRM2 H. sapiens SDL Slorth 0.980049 View
ENSG00000115592 PRKAG3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980045 View
ENSG00000025796 SEC63 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980043 View
ENSG00000146648 EGFR ENSG00000184937 WT1 H. sapiens SDL Slorth 0.98003 View
ENSG00000105737 GRIK5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980028 View
ENSG00000146648 EGFR ENSG00000185338 SOCS1 H. sapiens SDL Slorth 0.980023 View
ENSG00000101350 KIF3B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980018 View
ENSG00000080345 RIF1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.98001 View
ENSG00000007168 PAFAH1B1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.980001 View
ENSG00000145632 PLK2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97999 View
ENSG00000146648 EGFR ENSG00000174903 RAB1B H. sapiens SDL Slorth 0.979984 View
ENSG00000109471 IL2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979983 View
ENSG00000005884 ITGA3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979978 View
ENSG00000130766 SESN2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979977 View
ENSG00000110031 LPXN ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979964 View
ENSG00000107807 TLX1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979952 View
ENSG00000146648 EGFR ENSG00000185811 IKZF1 H. sapiens SDL Slorth 0.979942 View
ENSG00000146648 EGFR ENSG00000152086 TUBA3E H. sapiens SDL Slorth 0.97994 View
ENSG00000125967 NECAB3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979938 View
ENSG00000146648 EGFR ENSG00000170881 RNF139 H. sapiens SDL Slorth 0.979934 View
ENSG00000075340 ADD2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979899 View
ENSG00000077254 USP33 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979895 View
ENSG00000146648 EGFR ENSG00000254445 HSPB2-C11orf52 H. sapiens SDL Slorth 0.97989 View
ENSG00000146648 EGFR ENSG00000177731 FLII H. sapiens SDL Slorth 0.979868 View
ENSG00000139998 RAB15 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979849 View
ENSG00000133818 RRAS2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979839 View