EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000120500 ARR3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979392 View
ENSG00000146648 EGFR ENSG00000213465 ARL2 H. sapiens SDL Slorth 0.979337 View
ENSG00000146648 EGFR ENSG00000151729 SLC25A4 H. sapiens SDL Slorth 0.979327 View
ENSG00000131475 VPS25 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979291 View
ENSG00000108387 SEPT4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979288 View
ENSG00000125885 MCM8 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97927 View
ENSG00000110777 POU2AF1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979263 View
ENSG00000146648 EGFR ENSG00000150907 FOXO1 H. sapiens SDL Slorth 0.979251 View
ENSG00000146648 EGFR ENSG00000173334 TRIB1 H. sapiens SDL Slorth 0.979228 View
ENSG00000007944 MYLIP ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979221 View
ENSG00000146648 EGFR ENSG00000170734 POLH H. sapiens SDL Slorth 0.979199 View
ENSG00000146648 EGFR ENSG00000161800 RACGAP1 H. sapiens SDL Slorth 0.979192 View
ENSG00000073060 SCARB1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979189 View
ENSG00000132386 SERPINF1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979185 View
ENSG00000055917 PUM2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979169 View
ENSG00000136237 RAPGEF5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979155 View
ENSG00000112246 SIM1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979117 View
ENSG00000079337 RAPGEF3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979092 View
ENSG00000139668 WDFY2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979091 View
ENSG00000146648 EGFR ENSG00000225830 ERCC6 H. sapiens SDL Slorth 0.979086 View
ENSG00000128683 GAD1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979066 View
ENSG00000130764 LRRC47 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979063 View
ENSG00000146648 EGFR ENSG00000179583 CIITA H. sapiens SDL Slorth 0.979051 View
ENSG00000146648 EGFR ENSG00000177272 KCNA3 H. sapiens SDL Slorth 0.979049 View
ENSG00000134852 CLOCK ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97903 View
ENSG00000085185 BCORL1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979027 View
ENSG00000146648 EGFR ENSG00000151067 CACNA1C H. sapiens SDL Slorth 0.979019 View
ENSG00000090621 PABPC4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979008 View
ENSG00000120063 GNA13 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978982 View
ENSG00000121152 NCAPH ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978955 View
ENSG00000146648 EGFR ENSG00000175305 CCNE2 H. sapiens SDL Slorth 0.978947 View
ENSG00000146648 EGFR ENSG00000183337 BCOR H. sapiens SDL Slorth 0.978944 View
ENSG00000146648 EGFR ENSG00000151090 THRB H. sapiens SDL Slorth 0.978922 View
ENSG00000146648 EGFR ENSG00000162613 FUBP1 H. sapiens SDL Slorth 0.978912 View
ENSG00000105443 CYTH2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978895 View
ENSG00000066777 ARFGEF1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978884 View
ENSG00000119396 RAB14 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978878 View
ENSG00000146648 EGFR ENSG00000176749 CDK5R1 H. sapiens SDL Slorth 0.978878 View
ENSG00000146232 NFKBIE ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978864 View
ENSG00000092531 SNAP23 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978852 View