EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000006468 ETV1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979834 View
ENSG00000146648 EGFR ENSG00000169564 PCBP1 H. sapiens SDL Slorth 0.979833 View
ENSG00000123908 AGO2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97983 View
ENSG00000146648 EGFR ENSG00000171109 MFN1 H. sapiens SDL Slorth 0.979826 View
ENSG00000146648 EGFR ENSG00000198742 SMURF1 H. sapiens SDL Slorth 0.979824 View
ENSG00000072415 MPP5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979806 View
ENSG00000078114 NEBL ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979802 View
ENSG00000137996 RTCA ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97977 View
ENSG00000079335 CDC14A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979759 View
ENSG00000146648 EGFR ENSG00000213672 NCKIPSD H. sapiens SDL Slorth 0.979753 View
ENSG00000106617 PRKAG2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979751 View
ENSG00000101040 ZMYND8 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979746 View
ENSG00000136631 VPS45 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979735 View
ENSG00000112367 FIG4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979733 View
ENSG00000100311 PDGFB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979721 View
ENSG00000100934 SEC23A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979719 View
ENSG00000100505 TRIM9 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979699 View
ENSG00000005844 ITGAL ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979697 View
ENSG00000146648 EGFR ENSG00000166900 STX3 H. sapiens SDL Slorth 0.97969 View
ENSG00000105146 AURKC ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979667 View
ENSG00000109572 CLCN3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979655 View
ENSG00000146648 EGFR ENSG00000169756 LIMS1 H. sapiens SDL Slorth 0.97965 View
ENSG00000142273 CBLC ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979638 View
ENSG00000137497 NUMA1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979637 View
ENSG00000146648 EGFR ENSG00000198258 UBL5 H. sapiens SDL Slorth 0.979627 View
ENSG00000146648 EGFR ENSG00000180198 RCC1 H. sapiens SDL Slorth 0.979625 View
ENSG00000146648 EGFR ENSG00000198836 OPA1 H. sapiens SDL Slorth 0.979622 View
ENSG00000105993 DNAJB6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979596 View
ENSG00000146648 EGFR ENSG00000147274 RBMX H. sapiens SDL Slorth 0.979575 View
ENSG00000014216 CAPN1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979537 View
ENSG00000146648 EGFR ENSG00000160224 AIRE H. sapiens SDL Slorth 0.979534 View
ENSG00000143867 OSR1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979502 View
ENSG00000146648 EGFR ENSG00000163624 CDS1 H. sapiens SDL Slorth 0.979502 View
ENSG00000048540 LMO3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979473 View
ENSG00000085999 RAD54L ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979464 View
ENSG00000146648 EGFR ENSG00000179094 PER1 H. sapiens SDL Slorth 0.979457 View
ENSG00000065534 MYLK ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979447 View
ENSG00000146648 EGFR ENSG00000255112 CHMP1B H. sapiens SDL Slorth 0.979415 View
ENSG00000144134 RABL2A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979415 View
ENSG00000100852 ARHGAP5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.979392 View