EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000146648 EGFR ENSG00000173402 DAG1 H. sapiens SDL Slorth 0.978846 View
ENSG00000115317 HTRA2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978826 View
ENSG00000134352 IL6ST ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978811 View
ENSG00000072364 AFF4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978802 View
ENSG00000113240 CLK4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978794 View
ENSG00000146648 EGFR ENSG00000186298 PPP1CC H. sapiens SDL Slorth 0.978793 View
ENSG00000132781 MUTYH ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978769 View
ENSG00000116641 DOCK7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978768 View
ENSG00000074219 TEAD2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978765 View
ENSG00000138756 BMP2K ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978764 View
ENSG00000124198 ARFGEF2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978753 View
ENSG00000146457 WTAP ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978748 View
ENSG00000108799 EZH1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978733 View
ENSG00000092841 MYL6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978703 View
ENSG00000131653 TRAF7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978703 View
ENSG00000081377 CDC14B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978685 View
ENSG00000143569 UBAP2L ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978658 View
ENSG00000120533 ENY2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978653 View
ENSG00000080371 RAB21 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978644 View
ENSG00000146648 EGFR ENSG00000152137 HSPB8 H. sapiens SDL Slorth 0.978636 View
ENSG00000146648 EGFR ENSG00000155363 MOV10 H. sapiens SDL Slorth 0.978618 View
ENSG00000146648 EGFR ENSG00000196576 PLXNB2 H. sapiens SDL Slorth 0.978584 View
ENSG00000134371 CDC73 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97857 View
ENSG00000104517 UBR5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978568 View
ENSG00000076928 ARHGEF1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97853 View
ENSG00000146648 EGFR ENSG00000173812 EIF1 H. sapiens SDL Slorth 0.978529 View
ENSG00000146648 EGFR ENSG00000158604 TMED4 H. sapiens SDL Slorth 0.978505 View
ENSG00000146648 EGFR ENSG00000157168 NRG1 H. sapiens SDL Slorth 0.978468 View
ENSG00000146648 EGFR ENSG00000186350 RXRA H. sapiens SDL Slorth 0.978423 View
ENSG00000004059 ARF5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978417 View
ENSG00000146648 EGFR ENSG00000247077 PGAM5 H. sapiens SDL Slorth 0.978412 View
ENSG00000061918 GUCY1B3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978404 View
ENSG00000013561 RNF14 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978403 View
ENSG00000072315 TRPC5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978396 View
ENSG00000083290 ULK2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978394 View
ENSG00000091073 DTX2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978368 View
ENSG00000146648 EGFR ENSG00000178209 PLEC H. sapiens SDL Slorth 0.978365 View
ENSG00000146648 EGFR ENSG00000172175 MALT1 H. sapiens SDL Slorth 0.978362 View
ENSG00000113569 NUP155 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.978353 View
ENSG00000146648 EGFR ENSG00000168646 AXIN2 H. sapiens SDL Slorth 0.978333 View