EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000072163 LIMS2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976934 View
ENSG00000115325 DOK1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976913 View
ENSG00000101310 SEC23B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976867 View
ENSG00000146648 EGFR ENSG00000165637 VDAC2 H. sapiens SDL Slorth 0.976857 View
ENSG00000072694 FCGR2B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97685 View
ENSG00000130561 SAG ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976838 View
ENSG00000115738 ID2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97682 View
ENSG00000117707 PROX1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976798 View
ENSG00000135930 EIF4E2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976791 View
ENSG00000067082 KLF6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976775 View
ENSG00000146648 EGFR ENSG00000160868 CYP3A4 H. sapiens SDL Slorth 0.97677 View
ENSG00000107295 SH3GL2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976769 View
ENSG00000100461 RBM23 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976764 View
ENSG00000146648 EGFR ENSG00000155846 PPARGC1B H. sapiens SDL Slorth 0.97676 View
ENSG00000108830 RND2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976746 View
ENSG00000117984 CTSD ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976739 View
ENSG00000140983 RHOT2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976717 View
ENSG00000112144 ICK ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976716 View
ENSG00000146648 EGFR ENSG00000168453 HR H. sapiens SDL Slorth 0.976713 View
ENSG00000135903 PAX3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976709 View
ENSG00000105329 TGFB1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976707 View
ENSG00000075651 PLD1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.9767 View
ENSG00000146648 EGFR ENSG00000173110 HSPA6 H. sapiens SDL Slorth 0.97669 View
ENSG00000077092 RARB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976677 View
ENSG00000120251 GRIA2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976676 View
ENSG00000146648 EGFR ENSG00000148688 RPP30 H. sapiens SDL Slorth 0.97667 View
ENSG00000056097 ZFR ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976664 View
ENSG00000143556 S100A7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976662 View
ENSG00000146648 EGFR ENSG00000183684 ALYREF H. sapiens SDL Slorth 0.976659 View
ENSG00000107796 ACTA2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976654 View
ENSG00000119699 TGFB3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976649 View
ENSG00000113594 LIFR ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976645 View
ENSG00000146648 EGFR ENSG00000175029 CTBP2 H. sapiens SDL Slorth 0.976629 View
ENSG00000124216 SNAI1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976619 View
ENSG00000116675 DNAJC6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976612 View
ENSG00000143476 DTL ENSG00000146648 EGFR H. sapiens SDL Slorth 0.9766 View
ENSG00000146648 EGFR ENSG00000174405 LIG4 H. sapiens SDL Slorth 0.976597 View
ENSG00000114423 CBLB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976558 View
ENSG00000141380 SS18 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976524 View
ENSG00000028277 POU2F2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976507 View