EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000065613 SLK ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976506 View
ENSG00000125084 WNT1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976503 View
ENSG00000118680 MYL12B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976496 View
ENSG00000146648 EGFR ENSG00000204389 HSPA1A H. sapiens SDL Slorth 0.976486 View
ENSG00000146648 EGFR ENSG00000196911 KPNA5 H. sapiens SDL Slorth 0.97647 View
ENSG00000143882 ATP6V1C2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976467 View
ENSG00000131400 NAPSA ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976404 View
ENSG00000137942 FNBP1L ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976355 View
ENSG00000146648 EGFR ENSG00000183853 KIRREL H. sapiens SDL Slorth 0.976342 View
ENSG00000058404 CAMK2B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976326 View
ENSG00000146648 EGFR ENSG00000181929 PRKAG1 H. sapiens SDL Slorth 0.976303 View
ENSG00000139726 DENR ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976299 View
ENSG00000007866 TEAD3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976282 View
ENSG00000145331 TRMT10A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976277 View
ENSG00000143252 SDHC ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976277 View
ENSG00000136158 SPRY2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976263 View
ENSG00000103111 MON1B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976259 View
ENSG00000125740 FOSB ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976256 View
ENSG00000108861 DUSP3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976242 View
ENSG00000146648 EGFR ENSG00000175093 SPSB4 H. sapiens SDL Slorth 0.976215 View
ENSG00000132330 SCLY ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976211 View
ENSG00000018408 WWTR1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976204 View
ENSG00000115760 BIRC6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976167 View
ENSG00000100650 SRSF5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976161 View
ENSG00000070159 PTPN3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976153 View
ENSG00000107929 LARP4B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976133 View
ENSG00000085382 HACE1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97612 View
ENSG00000146648 EGFR ENSG00000169439 SDC2 H. sapiens SDL Slorth 0.976119 View
ENSG00000137270 GCM1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976098 View
ENSG00000139352 ASCL1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976097 View
ENSG00000087460 GNAS ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976061 View
ENSG00000119335 SET ENSG00000146648 EGFR H. sapiens SDL Slorth 0.976047 View
ENSG00000057294 PKP2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975996 View
ENSG00000131899 LLGL1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975987 View
ENSG00000075618 FSCN1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975986 View
ENSG00000128607 KLHDC10 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975979 View
ENSG00000102781 KATNAL1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975979 View
ENSG00000128271 ADORA2A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975979 View
ENSG00000122180 MYOG ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97597 View
ENSG00000146648 EGFR ENSG00000162409 PRKAA2 H. sapiens SDL Slorth 0.975951 View