EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000124571 XPO5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975399 View
ENSG00000101752 MIB1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975399 View
ENSG00000146648 EGFR ENSG00000178295 GEN1 H. sapiens SDL Slorth 0.975357 View
ENSG00000140307 GTF2A2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975349 View
ENSG00000146648 EGFR ENSG00000204390 HSPA1L H. sapiens SDL Slorth 0.975345 View
ENSG00000146648 EGFR ENSG00000196470 SIAH1 H. sapiens SDL Slorth 0.975343 View
ENSG00000146648 EGFR ENSG00000170832 USP32 H. sapiens SDL Slorth 0.975342 View
ENSG00000105976 MET ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975323 View
ENSG00000091409 ITGA6 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975299 View
ENSG00000131504 DIAPH1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975295 View
ENSG00000146648 EGFR ENSG00000173020 GRK2 H. sapiens SDL Slorth 0.975294 View
ENSG00000084764 MAPRE3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975257 View
ENSG00000101251 SEL1L2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975248 View
ENSG00000146648 EGFR ENSG00000187323 DCC H. sapiens SDL Slorth 0.97524 View
ENSG00000146648 EGFR ENSG00000187735 TCEA1 H. sapiens SDL Slorth 0.975237 View
ENSG00000086598 TMED2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975229 View
ENSG00000114127 XRN1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97522 View
ENSG00000146648 EGFR ENSG00000197694 SPTAN1 H. sapiens SDL Slorth 0.975196 View
ENSG00000146648 EGFR ENSG00000204843 DCTN1 H. sapiens SDL Slorth 0.975185 View
ENSG00000115266 APC2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975177 View
ENSG00000146648 EGFR ENSG00000155304 HSPA13 H. sapiens SDL Slorth 0.975164 View
ENSG00000137267 TUBB2A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975162 View
ENSG00000143344 RGL1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97516 View
ENSG00000146648 EGFR ENSG00000196961 AP2A1 H. sapiens SDL Slorth 0.975141 View
ENSG00000064651 SLC12A2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975115 View
ENSG00000146648 EGFR ENSG00000164867 NOS3 H. sapiens SDL Slorth 0.975108 View
ENSG00000132471 WBP2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975091 View
ENSG00000109911 ELP4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975088 View
ENSG00000049245 VAMP3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975049 View
ENSG00000146648 EGFR ENSG00000185344 ATP6V0A2 H. sapiens SDL Slorth 0.975014 View
ENSG00000133216 EPHB2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.975007 View
ENSG00000146648 EGFR ENSG00000159210 SNF8 H. sapiens SDL Slorth 0.974952 View
ENSG00000133056 PIK3C2B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.974946 View
ENSG00000146648 EGFR ENSG00000179776 CDH5 H. sapiens SDL Slorth 0.974938 View
ENSG00000101349 PAK5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.974924 View
ENSG00000102034 ELF4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.974914 View
ENSG00000112984 KIF20A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.974897 View
ENSG00000119655 NPC2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.97489 View
ENSG00000097033 SH3GLB1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.974874 View
ENSG00000146648 EGFR ENSG00000157540 DYRK1A H. sapiens SDL Slorth 0.974873 View