EGFR

ENSG00000146648 - H. sapiens

Pathways

Go term Description
GO:0001948 glycoprotein binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0030235 nitric-oxide synthase regulator activity
GO:0019904 protein domain specific binding

Drugs

Drug name Description
AFATINIB Epidermal growth factor receptor erbB1 inhibitor
CETUXIMAB Epidermal growth factor receptor erbB1 inhibitor
ERLOTINIB Epidermal growth factor receptor erbB1 inhibitor
GEFITINIB Epidermal growth factor receptor erbB1 inhibitor
LAPATINIB Epidermal growth factor receptor erbB1 inhibitor
PANITUMUMAB Epidermal growth factor receptor erbB1 inhibitor
VANDETANIB Epidermal growth factor receptor inhibitor

Diseases

Disease Name
glioma
NSCLC

Orthologs

Gene Organism
let-23 C. elegans
Egfr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000135424 ITGA7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977804 View
ENSG00000146648 EGFR ENSG00000167553 TUBA1C H. sapiens SDL Slorth 0.977768 View
ENSG00000146648 EGFR ENSG00000164695 CHMP4C H. sapiens SDL Slorth 0.977763 View
ENSG00000060237 WNK1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977713 View
ENSG00000146648 EGFR ENSG00000169189 NSMCE1 H. sapiens SDL Slorth 0.977712 View
ENSG00000061676 NCKAP1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977685 View
ENSG00000111252 SH2B3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977649 View
ENSG00000108947 EFNB3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977645 View
ENSG00000146648 EGFR ENSG00000169714 CNBP H. sapiens SDL Slorth 0.97764 View
ENSG00000099365 STX1B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977619 View
ENSG00000146648 EGFR ENSG00000166477 LEO1 H. sapiens SDL Slorth 0.977616 View
ENSG00000144736 SHQ1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.9776 View
ENSG00000146648 EGFR ENSG00000163041 H3F3A H. sapiens SDL Slorth 0.977599 View
ENSG00000146648 EGFR ENSG00000198911 SREBF2 H. sapiens SDL Slorth 0.977598 View
ENSG00000100632 ERH ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977588 View
ENSG00000117020 AKT3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977587 View
ENSG00000105204 DYRK1B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977583 View
ENSG00000066230 SLC9A3 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977578 View
ENSG00000124232 RBPJL ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977564 View
ENSG00000143033 MTF2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977563 View
ENSG00000118985 ELL2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977528 View
ENSG00000048392 RRM2B ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977485 View
ENSG00000146648 EGFR ENSG00000183735 TBK1 H. sapiens SDL Slorth 0.977475 View
ENSG00000116473 RAP1A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977453 View
ENSG00000138468 SENP7 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977444 View
ENSG00000111424 VDR ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977435 View
ENSG00000146648 EGFR ENSG00000175203 DCTN2 H. sapiens SDL Slorth 0.977414 View
ENSG00000132669 RIN2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977406 View
ENSG00000029363 BCLAF1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977403 View
ENSG00000131558 EXOC4 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.9774 View
ENSG00000082781 ITGB5 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977399 View
ENSG00000129514 FOXA1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977387 View
ENSG00000101384 JAG1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977386 View
ENSG00000007264 MATK ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977373 View
ENSG00000124784 RIOK1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977356 View
ENSG00000146648 EGFR ENSG00000163161 ERCC3 H. sapiens SDL Slorth 0.97735 View
ENSG00000063660 GPC1 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977348 View
ENSG00000146648 EGFR ENSG00000170027 YWHAG H. sapiens SDL Slorth 0.977322 View
ENSG00000126583 PRKCG ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977321 View
ENSG00000071242 RPS6KA2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.977309 View