JAK2

ENSG00000096968 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005102 receptor binding
GO:0005131 growth hormone receptor binding
GO:0005143 interleukin-12 receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0020037 heme binding
GO:0031702 type 1 angiotensin receptor binding
GO:0033130 acetylcholine receptor binding
GO:0035401 histone kinase activity (H3-Y41 specific)
GO:0042169 SH2 domain binding
GO:0042393 histone binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043560 insulin receptor substrate binding
GO:0046872 metal ion binding
GO:0051428 peptide hormone receptor binding

Drugs

Drug name Description
RUXOLITINIB Tyrosine-protein kinase JAK2 inhibitor
TOFACITINIB Janus Kinase (JAK) inhibitor

Diseases

Disease Name
ALL
AML
MPN
CML

Orthologs

Gene Organism
hop D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000096968 JAK2 ENSG00000145675 PIK3R1 H. sapiens SSL BioGRID 1.0 View
ENSG00000091831 ESR1 ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.991105 View
ENSG00000072736 NFATC3 ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.984208 View
ENSG00000088367 EPB41L1 ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.983622 View
ENSG00000079156 OSBPL6 ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.983572 View
ENSG00000067829 IDH3G ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.983563 View
ENSG00000077380 DYNC1I2 ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.98338 View
ENSG00000096968 JAK2 ENSG00000154447 SH3RF1 H. sapiens SDL Slorth 0.983186 View
ENSG00000096968 JAK2 ENSG00000156299 TIAM1 H. sapiens SDL Slorth 0.982741 View
ENSG00000096968 JAK2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.982686 View
ENSG00000096968 JAK2 ENSG00000143556 S100A7 H. sapiens SDL Slorth 0.982634 View
ENSG00000096968 JAK2 ENSG00000180176 TH H. sapiens SDL Slorth 0.982629 View
ENSG00000096968 JAK2 ENSG00000213672 NCKIPSD H. sapiens SDL Slorth 0.982424 View
ENSG00000096968 JAK2 ENSG00000105245 NUMBL H. sapiens SDL Slorth 0.982201 View
ENSG00000096968 JAK2 ENSG00000100968 NFATC4 H. sapiens SDL Slorth 0.982062 View
ENSG00000086619 ERO1B ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.981966 View
ENSG00000077935 SMC1B ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.981916 View
ENSG00000070718 AP3M2 ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.981568 View
ENSG00000079335 CDC14A ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.981336 View
ENSG00000096968 JAK2 ENSG00000157168 NRG1 H. sapiens SDL Slorth 0.981282 View
ENSG00000096968 JAK2 ENSG00000139318 DUSP6 H. sapiens SDL Slorth 0.981174 View
ENSG00000096968 JAK2 ENSG00000169372 CRADD H. sapiens SDL Slorth 0.981138 View
ENSG00000021574 SPAST ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.981135 View
ENSG00000096968 JAK2 ENSG00000171621 SPSB1 H. sapiens SDL Slorth 0.981029 View
ENSG00000096968 JAK2 ENSG00000175093 SPSB4 H. sapiens SDL Slorth 0.981029 View
ENSG00000096968 JAK2 ENSG00000114737 CISH H. sapiens SDL Slorth 0.981001 View
ENSG00000096968 JAK2 ENSG00000107036 RIC1 H. sapiens SDL Slorth 0.980939 View
ENSG00000096968 JAK2 ENSG00000100092 SH3BP1 H. sapiens SDL Slorth 0.980713 View
ENSG00000096968 JAK2 ENSG00000205629 LCMT1 H. sapiens SDL Slorth 0.980386 View
ENSG00000072163 LIMS2 ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.980187 View
ENSG00000049323 LTBP1 ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.980145 View
ENSG00000096968 JAK2 ENSG00000157514 TSC22D3 H. sapiens SDL Slorth 0.980136 View
ENSG00000096968 JAK2 ENSG00000155849 ELMO1 H. sapiens SDL Slorth 0.980087 View
ENSG00000096968 JAK2 ENSG00000120539 MASTL H. sapiens SDL Slorth 0.979832 View
ENSG00000096968 JAK2 ENSG00000137843 PAK6 H. sapiens SDL Slorth 0.979804 View
ENSG00000096968 JAK2 ENSG00000119866 BCL11A H. sapiens SDL Slorth 0.97975 View
ENSG00000005339 CREBBP ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.979511 View
ENSG00000066923 STAG3 ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.979476 View
ENSG00000096968 JAK2 ENSG00000244405 ETV5 H. sapiens SDL Slorth 0.979441 View
ENSG00000041353 RAB27B ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.979424 View