JAK2

ENSG00000096968 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005102 receptor binding
GO:0005131 growth hormone receptor binding
GO:0005143 interleukin-12 receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0020037 heme binding
GO:0031702 type 1 angiotensin receptor binding
GO:0033130 acetylcholine receptor binding
GO:0035401 histone kinase activity (H3-Y41 specific)
GO:0042169 SH2 domain binding
GO:0042393 histone binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043560 insulin receptor substrate binding
GO:0046872 metal ion binding
GO:0051428 peptide hormone receptor binding

Drugs

Drug name Description
RUXOLITINIB Tyrosine-protein kinase JAK2 inhibitor
TOFACITINIB Janus Kinase (JAK) inhibitor

Diseases

Disease Name
ALL
AML
MPN
CML

Orthologs

Gene Organism
hop D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000096968 JAK2 ENSG00000100505 TRIM9 H. sapiens SDL Slorth 0.976376 View
ENSG00000096968 JAK2 ENSG00000169800 RBMY1F H. sapiens SDL Slorth 0.976244 View
ENSG00000096968 JAK2 ENSG00000213949 ITGA1 H. sapiens SDL Slorth 0.97623 View
ENSG00000096968 JAK2 ENSG00000165506 DNAAF2 H. sapiens SDL Slorth 0.976218 View
ENSG00000077279 DCX ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.976191 View
ENSG00000007908 SELE ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.976138 View
ENSG00000041982 TNC ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.976107 View
ENSG00000096968 JAK2 ENSG00000169926 KLF13 H. sapiens SDL Slorth 0.976012 View
ENSG00000087995 METTL2A ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.975998 View
ENSG00000096968 JAK2 ENSG00000115355 CCDC88A H. sapiens SDL Slorth 0.975788 View
ENSG00000096968 JAK2 ENSG00000214102 WEE2 H. sapiens SDL Slorth 0.975779 View
ENSG00000085185 BCORL1 ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.975684 View
ENSG00000096968 JAK2 ENSG00000104881 PPP1R13L H. sapiens SDL Slorth 0.975626 View
ENSG00000096968 JAK2 ENSG00000189067 LITAF H. sapiens SDL Slorth 0.975512 View
ENSG00000096968 JAK2 ENSG00000135605 TEC H. sapiens SDL Slorth 0.975489 View
ENSG00000096968 JAK2 ENSG00000185697 MYBL1 H. sapiens SDL Slorth 0.975486 View
ENSG00000079432 CIC ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.975438 View
ENSG00000096968 JAK2 ENSG00000100393 EP300 H. sapiens SDL Slorth 0.975396 View
ENSG00000096968 JAK2 ENSG00000168646 AXIN2 H. sapiens SDL Slorth 0.975393 View
ENSG00000096968 JAK2 ENSG00000155090 KLF10 H. sapiens SDL Slorth 0.975369 View
ENSG00000096968 JAK2 ENSG00000171150 SOCS5 H. sapiens SDL Slorth 0.975344 View
ENSG00000095397 WHRN ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.975224 View
ENSG00000096968 JAK2 ENSG00000188130 MAPK12 H. sapiens SDL Slorth 0.975223 View
ENSG00000096968 JAK2 ENSG00000163098 BIRC8 H. sapiens SDL Slorth 0.975121 View
ENSG00000096968 JAK2 ENSG00000112144 ICK H. sapiens SDL Slorth 0.975052 View
ENSG00000008853 RHOBTB2 ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.975015 View
ENSG00000072422 RHOBTB1 ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.975015 View
ENSG00000010671 BTK ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.974971 View
ENSG00000096968 JAK2 ENSG00000197122 SRC H. sapiens SDL Slorth 0.974925 View
ENSG00000074219 TEAD2 ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.9749 View
ENSG00000096968 JAK2 ENSG00000185896 LAMP1 H. sapiens SDL Slorth 0.974854 View
ENSG00000096968 JAK2 ENSG00000101213 PTK6 H. sapiens SDL Slorth 0.974786 View
ENSG00000096968 JAK2 ENSG00000169714 CNBP H. sapiens SDL Slorth 0.974717 View
ENSG00000096968 JAK2 ENSG00000100614 PPM1A H. sapiens SDL Slorth 0.974698 View
ENSG00000096968 JAK2 ENSG00000126561 STAT5A H. sapiens SDL Slorth 0.974543 View
ENSG00000070476 ZXDC ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.974472 View
ENSG00000096968 JAK2 ENSG00000185386 MAPK11 H. sapiens SDL Slorth 0.974428 View
ENSG00000090889 KIF4A ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.974398 View
ENSG00000096968 JAK2 ENSG00000172071 EIF2AK3 H. sapiens SDL Slorth 0.974169 View
ENSG00000096968 JAK2 ENSG00000115290 GRB14 H. sapiens SDL Slorth 0.974067 View