JAK2

ENSG00000096968 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005102 receptor binding
GO:0005131 growth hormone receptor binding
GO:0005143 interleukin-12 receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0020037 heme binding
GO:0031702 type 1 angiotensin receptor binding
GO:0033130 acetylcholine receptor binding
GO:0035401 histone kinase activity (H3-Y41 specific)
GO:0042169 SH2 domain binding
GO:0042393 histone binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043560 insulin receptor substrate binding
GO:0046872 metal ion binding
GO:0051428 peptide hormone receptor binding

Drugs

Drug name Description
RUXOLITINIB Tyrosine-protein kinase JAK2 inhibitor
TOFACITINIB Janus Kinase (JAK) inhibitor

Diseases

Disease Name
ALL
AML
MPN
CML

Orthologs

Gene Organism
hop D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000096968 JAK2 ENSG00000160145 KALRN H. sapiens SDL Slorth 0.973991 View
ENSG00000096968 JAK2 ENSG00000141448 GATA6 H. sapiens SDL Slorth 0.973975 View
ENSG00000096968 JAK2 ENSG00000136237 RAPGEF5 H. sapiens SDL Slorth 0.973939 View
ENSG00000096968 JAK2 ENSG00000173404 INSM1 H. sapiens SDL Slorth 0.973814 View
ENSG00000075340 ADD2 ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.97373 View
ENSG00000063660 GPC1 ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.97373 View
ENSG00000096968 JAK2 ENSG00000168421 RHOH H. sapiens SDL Slorth 0.973685 View
ENSG00000096968 JAK2 ENSG00000100485 SOS2 H. sapiens SDL Slorth 0.973658 View
ENSG00000096968 JAK2 ENSG00000155846 PPARGC1B H. sapiens SDL Slorth 0.973547 View
ENSG00000080824 HSP90AA1 ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.97344 View
ENSG00000096968 JAK2 ENSG00000184012 TMPRSS2 H. sapiens SDL Slorth 0.973398 View
ENSG00000004848 ARX ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.973362 View
ENSG00000096968 JAK2 ENSG00000162889 MAPKAPK2 H. sapiens SDL Slorth 0.973213 View
ENSG00000096968 JAK2 ENSG00000165671 NSD1 H. sapiens SDL Slorth 0.973133 View
ENSG00000096968 JAK2 ENSG00000100721 TCL1A H. sapiens SDL Slorth 0.973106 View
ENSG00000096968 JAK2 ENSG00000178188 SH2B1 H. sapiens SDL Slorth 0.972964 View
ENSG00000096968 JAK2 ENSG00000179218 CALR H. sapiens SDL Slorth 0.972959 View
ENSG00000096968 JAK2 ENSG00000145632 PLK2 H. sapiens SDL Slorth 0.972861 View
ENSG00000096968 JAK2 ENSG00000124782 RREB1 H. sapiens SDL Slorth 0.972808 View
ENSG00000085999 RAD54L ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.97261 View
ENSG00000096968 JAK2 ENSG00000137825 ITPKA H. sapiens SDL Slorth 0.972534 View
ENSG00000096968 JAK2 ENSG00000157601 MX1 H. sapiens SDL Slorth 0.97251 View
ENSG00000096968 JAK2 ENSG00000113758 DBN1 H. sapiens SDL Slorth 0.972421 View
ENSG00000096968 JAK2 ENSG00000156475 PPP2R2B H. sapiens SDL Slorth 0.972297 View
ENSG00000096968 JAK2 ENSG00000152601 MBNL1 H. sapiens SDL Slorth 0.972136 View
ENSG00000096968 JAK2 ENSG00000124784 RIOK1 H. sapiens SDL Slorth 0.972122 View
ENSG00000079337 RAPGEF3 ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.972048 View
ENSG00000096968 JAK2 ENSG00000117625 RCOR3 H. sapiens SDL Slorth 0.971809 View
ENSG00000096968 JAK2 ENSG00000109320 NFKB1 H. sapiens SSL Slorth 0.971428 View
ENSG00000096968 JAK2 ENSG00000204389 HSPA1A H. sapiens SDL Slorth 0.97131 View
ENSG00000096968 JAK2 ENSG00000196911 KPNA5 H. sapiens SDL Slorth 0.971248 View
ENSG00000063438 AHRR ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.971114 View
ENSG00000096968 JAK2 ENSG00000143344 RGL1 H. sapiens SDL Slorth 0.971109 View
ENSG00000070404 FSTL3 ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.971047 View
ENSG00000096968 JAK2 ENSG00000169083 AR H. sapiens SDL Slorth 0.970994 View
ENSG00000096968 JAK2 ENSG00000152284 TCF7L1 H. sapiens SDL Slorth 0.970857 View
ENSG00000011454 RABGAP1 ENSG00000096968 JAK2 H. sapiens SDL Slorth 0.970576 View
ENSG00000096968 JAK2 ENSG00000172059 KLF11 H. sapiens SDL Slorth 0.970421 View
ENSG00000096968 JAK2 ENSG00000166192 SENP8 H. sapiens SDL Slorth 0.970215 View
ENSG00000096968 JAK2 ENSG00000157540 DYRK1A H. sapiens SDL Slorth 0.970191 View