BRAF

ENSG00000157764 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
GO:0031267 small GTPase binding

Drugs

Drug name Description
DABRAFENIB Serine/threonine-protein kinase B-raf inhibitor
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SORAFENIB Serine/threonine-protein kinase RAF inhibitor
VEMURAFENIB Serine/threonine-protein kinase B-raf inhibitor

Diseases

Disease Name
melanoma
colorectal
papillary thyroid
borderline ovarian
NSCLC
cholangiocarcinoma
pilocytic astrocytoma
Spitzoid tumour
pancreas acinar carcinoma
melanocytic nevus
prostate
gastric

Orthologs

Gene Organism
lin-45 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000157764 BRAF ENSG00000198911 SREBF2 H. sapiens SDL Slorth 0.940017 View
ENSG00000157764 BRAF ENSG00000185697 MYBL1 H. sapiens SDL Slorth 0.939933 View
ENSG00000149269 PAK1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.9397 View
ENSG00000157764 BRAF ENSG00000181449 SOX2 H. sapiens SDL Slorth 0.939414 View
ENSG00000112576 CCND3 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.939407 View
ENSG00000157764 BRAF ENSG00000171824 EXOSC10 H. sapiens SSL Slorth 0.939308 View
ENSG00000104375 STK3 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.939165 View
ENSG00000157764 BRAF ENSG00000186716 BCR H. sapiens SSL Slorth 0.93912 View
ENSG00000156603 MED19 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.939003 View
ENSG00000114423 CBLB ENSG00000157764 BRAF H. sapiens SSL Slorth 0.938871 View
ENSG00000120438 TCP1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.938765 View
ENSG00000074266 EED ENSG00000157764 BRAF H. sapiens SSL Slorth 0.938716 View
ENSG00000116044 NFE2L2 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.938598 View
ENSG00000138663 COPS4 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.938453 View
ENSG00000157764 BRAF ENSG00000175104 TRAF6 H. sapiens SSL Slorth 0.938361 View
ENSG00000075785 RAB7A ENSG00000157764 BRAF H. sapiens SSL Slorth 0.93833 View
ENSG00000157764 BRAF ENSG00000220205 VAMP2 H. sapiens SDL Slorth 0.938115 View
ENSG00000157764 BRAF ENSG00000166167 BTRC H. sapiens SSL Slorth 0.938094 View
ENSG00000157764 BRAF ENSG00000169252 ADRB2 H. sapiens SSL Slorth 0.938069 View
ENSG00000141968 VAV1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.938038 View
ENSG00000157764 BRAF ENSG00000213923 CSNK1E H. sapiens SDL Slorth 0.937957 View
ENSG00000113812 ACTR8 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.937948 View
ENSG00000068024 HDAC4 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.937765 View
ENSG00000116478 HDAC1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.937722 View
ENSG00000157764 BRAF ENSG00000163466 ARPC2 H. sapiens SDL Slorth 0.937598 View
ENSG00000157764 BRAF ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.937569 View
ENSG00000106263 EIF3B ENSG00000157764 BRAF H. sapiens SSL Slorth 0.937549 View
ENSG00000157764 BRAF ENSG00000178997 EXD1 H. sapiens SDL Slorth 0.937354 View
ENSG00000157764 BRAF ENSG00000168496 FEN1 H. sapiens SDL Slorth 0.937352 View
ENSG00000157764 BRAF ENSG00000198258 UBL5 H. sapiens SSL Slorth 0.937332 View
ENSG00000157764 BRAF ENSG00000204389 HSPA1A H. sapiens SDL Slorth 0.937312 View
ENSG00000157764 BRAF ENSG00000197442 MAP3K5 H. sapiens SSL Slorth 0.937245 View
ENSG00000136450 SRSF1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.937221 View
ENSG00000157764 BRAF ENSG00000175093 SPSB4 H. sapiens SDL Slorth 0.937202 View
ENSG00000157764 BRAF ENSG00000171621 SPSB1 H. sapiens SDL Slorth 0.937202 View
ENSG00000110092 CCND1 ENSG00000157764 BRAF H. sapiens SDL Slorth 0.937176 View
ENSG00000077279 DCX ENSG00000157764 BRAF H. sapiens SDL Slorth 0.937164 View
ENSG00000147133 TAF1 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.937137 View
ENSG00000074319 TSG101 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.937135 View
ENSG00000077721 UBE2A ENSG00000157764 BRAF H. sapiens SSL Slorth 0.937096 View