MAP2K1

ENSG00000169032 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004728 signal transducer, downstream of receptor, with protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0047485 protein N-terminus binding

Drugs

Drug name Description
TRAMETINIB Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Diseases

Disease Name
NSCLC
melanoma
colorectal

Orthologs

Gene Organism
PBS2 S. cerevisiae
mek-2 C. elegans
Dsor1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000196591 HDAC2 ENSG00000169032 MAP2K1 H. sapiens SSL BioGRID 1.0 View
ENSG00000168395 ING5 ENSG00000169032 MAP2K1 H. sapiens SSL BioGRID 1.0 View
ENSG00000169032 MAP2K1 ENSG00000198793 MTOR H. sapiens SSL BioGRID 1.0 View
ENSG00000169032 MAP2K1 ENSG00000118046 STK11 H. sapiens SSL BioGRID 1.0 View
ENSG00000169032 MAP2K1 ENSG00000155657 TTN H. sapiens SSL BioGRID 1.0 View
ENSG00000169032 MAP2K1 ENSG00000104723 TUSC3 H. sapiens SSL BioGRID 1.0 View
ENSG00000169032 MAP2K1 ENSG00000134086 VHL H. sapiens SSL BioGRID 1.0 View
ENSG00000176208 ATAD5 ENSG00000169032 MAP2K1 H. sapiens SSL BioGRID 1.0 View
ENSG00000197299 BLM ENSG00000169032 MAP2K1 H. sapiens SSL BioGRID 1.0 View
ENSG00000157764 BRAF ENSG00000169032 MAP2K1 H. sapiens SSL BioGRID 1.0 View
ENSG00000141867 BRD4 ENSG00000169032 MAP2K1 H. sapiens SSL BioGRID 1.0 View
ENSG00000149554 CHEK1 ENSG00000169032 MAP2K1 H. sapiens SSL BioGRID 1.0 View
ENSG00000091483 FH ENSG00000169032 MAP2K1 H. sapiens SSL BioGRID 1.0 View
ENSG00000132646 PCNA ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.991715 View
ENSG00000136997 MYC ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.99005 View
ENSG00000012048 BRCA1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.98931 View
ENSG00000140464 PML ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.989026 View
ENSG00000005339 CREBBP ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.988975 View
ENSG00000139687 RB1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.988722 View
ENSG00000101266 CSNK2A1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.985363 View
ENSG00000162385 MAGOH ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.985112 View
ENSG00000124762 CDKN1A ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.9849 View
ENSG00000123374 CDK2 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.984618 View
ENSG00000104365 IKBKB ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.983679 View
ENSG00000100393 EP300 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.982992 View
ENSG00000103275 UBE2I ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.981118 View
ENSG00000100030 MAPK1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.981092 View
ENSG00000150991 UBC ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.979735 View
ENSG00000142208 AKT1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.979599 View
ENSG00000166167 BTRC ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.979423 View
ENSG00000116478 HDAC1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.978667 View
ENSG00000169032 MAP2K1 ENSG00000177606 JUN H. sapiens SDL Slorth 0.978382 View
ENSG00000100644 HIF1A ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.977962 View
ENSG00000169032 MAP2K1 ENSG00000189067 LITAF H. sapiens SDL Slorth 0.975927 View
ENSG00000166949 SMAD3 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.975467 View
ENSG00000169032 MAP2K1 ENSG00000170315 UBB H. sapiens SDL Slorth 0.975115 View
ENSG00000169032 MAP2K1 ENSG00000213949 ITGA1 H. sapiens SDL Slorth 0.975034 View
ENSG00000169032 MAP2K1 ENSG00000169862 CTNND2 H. sapiens SDL Slorth 0.974182 View
ENSG00000164305 CASP3 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.974018 View
ENSG00000141646 SMAD4 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.97374 View