MAP2K1

ENSG00000169032 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004728 signal transducer, downstream of receptor, with protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0047485 protein N-terminus binding

Drugs

Drug name Description
TRAMETINIB Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Diseases

Disease Name
NSCLC
melanoma
colorectal

Orthologs

Gene Organism
PBS2 S. cerevisiae
mek-2 C. elegans
Dsor1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000109971 HSPA8 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.927928 View
ENSG00000147010 SH3KBP1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.927893 View
ENSG00000087191 PSMC5 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.927667 View
ENSG00000169032 MAP2K1 ENSG00000170836 PPM1D H. sapiens SDL Slorth 0.927604 View
ENSG00000145386 CCNA2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.927511 View
ENSG00000169032 MAP2K1 ENSG00000253729 PRKDC H. sapiens SSL Slorth 0.927403 View
ENSG00000169032 MAP2K1 ENSG00000178997 EXD1 H. sapiens SDL Slorth 0.927329 View
ENSG00000136238 RAC1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.92718 View
ENSG00000114423 CBLB ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.927114 View
ENSG00000082898 XPO1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.927068 View
ENSG00000072803 FBXW11 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.926958 View
ENSG00000095015 MAP3K1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.926923 View
ENSG00000132170 PPARG ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.926899 View
ENSG00000169032 MAP2K1 ENSG00000180370 PAK2 H. sapiens SDL Slorth 0.92666 View
ENSG00000169032 MAP2K1 ENSG00000170345 FOS H. sapiens SDL Slorth 0.926462 View
ENSG00000106462 EZH2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.926063 View
ENSG00000091831 ESR1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.926023 View
ENSG00000169032 MAP2K1 ENSG00000183207 RUVBL2 H. sapiens SSL Slorth 0.925935 View
ENSG00000067560 RHOA ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.925869 View
ENSG00000143093 STRIP1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.925851 View
ENSG00000055130 CUL1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.925849 View
ENSG00000165280 VCP ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.925712 View
ENSG00000136628 EPRS ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.925494 View
ENSG00000166167 BTRC ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.925401 View
ENSG00000169032 MAP2K1 ENSG00000185651 UBE2L3 H. sapiens SSL Slorth 0.925247 View
ENSG00000036257 CUL3 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.925241 View
ENSG00000132341 RAN ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.925192 View
ENSG00000169032 MAP2K1 ENSG00000170365 SMAD1 H. sapiens SSL Slorth 0.924948 View
ENSG00000109971 HSPA8 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.924947 View
ENSG00000169032 MAP2K1 ENSG00000175054 ATR H. sapiens SSL Slorth 0.924941 View
ENSG00000151247 EIF4E ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.924604 View
ENSG00000110092 CCND1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.924474 View
ENSG00000072518 MARK2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.924405 View
ENSG00000163932 PRKCD ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.924388 View
ENSG00000108953 YWHAE ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.924367 View
ENSG00000169032 MAP2K1 ENSG00000197442 MAP3K5 H. sapiens SSL Slorth 0.92431 View
ENSG00000117748 RPA2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.924194 View
ENSG00000100911 PSME2 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.924166 View
ENSG00000169032 MAP2K1 ENSG00000183684 ALYREF H. sapiens SSL Slorth 0.923939 View
ENSG00000169032 MAP2K1 ENSG00000175387 SMAD2 H. sapiens SDL Slorth 0.923909 View