MAP2K1

ENSG00000169032 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004728 signal transducer, downstream of receptor, with protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0047485 protein N-terminus binding

Drugs

Drug name Description
TRAMETINIB Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Diseases

Disease Name
NSCLC
melanoma
colorectal

Orthologs

Gene Organism
PBS2 S. cerevisiae
mek-2 C. elegans
Dsor1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000100644 HIF1A ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.902421 View
ENSG00000127445 PIN1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.901733 View
ENSG00000143190 POU2F1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.901616 View
ENSG00000147604 RPL7 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.901576 View
ENSG00000099817 POLR2E ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.90081 View
ENSG00000100030 MAPK1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.900398 View
ENSG00000166226 CCT2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.900039 View
ENSG00000154582 TCEB1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.899702 View
ENSG00000141027 NCOR1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.89959 View
ENSG00000120438 TCP1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.899507 View
ENSG00000141968 VAV1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.899438 View
ENSG00000169032 MAP2K1 ENSG00000183735 TBK1 H. sapiens SSL Slorth 0.8992 View
ENSG00000169032 MAP2K1 ENSG00000184634 MED12 H. sapiens SSL Slorth 0.898928 View
ENSG00000044574 HSPA5 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.898744 View
ENSG00000169032 MAP2K1 ENSG00000196470 SIAH1 H. sapiens SSL Slorth 0.898423 View
ENSG00000136450 SRSF1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.898122 View
ENSG00000169032 MAP2K1 ENSG00000186716 BCR H. sapiens SSL Slorth 0.898091 View
ENSG00000085832 EPS15 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.89807 View
ENSG00000169032 MAP2K1 ENSG00000177606 JUN H. sapiens SSL Slorth 0.897943 View
ENSG00000135624 CCT7 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.89784 View
ENSG00000169032 MAP2K1 ENSG00000169750 RAC3 H. sapiens SSL Slorth 0.897737 View
ENSG00000099956 SMARCB1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.897406 View
ENSG00000115464 USP34 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.896901 View
ENSG00000140992 PDPK1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.896791 View
ENSG00000103479 RBL2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.895736 View
ENSG00000109320 NFKB1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.895661 View
ENSG00000099804 CDC34 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.894329 View
ENSG00000079134 THOC1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.893712 View
ENSG00000149311 ATM ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.892618 View
ENSG00000169032 MAP2K1 ENSG00000187608 ISG15 H. sapiens SSL Slorth 0.89243 View
ENSG00000169032 MAP2K1 ENSG00000179262 RAD23A H. sapiens SSL Slorth 0.891993 View
ENSG00000085511 MAP3K4 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.890948 View
ENSG00000159461 AMFR ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.890831 View
ENSG00000039068 CDH1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.890181 View
ENSG00000132964 CDK8 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.890067 View
ENSG00000080824 HSP90AA1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.889729 View
ENSG00000169032 MAP2K1 ENSG00000198625 MDM4 H. sapiens SSL Slorth 0.889482 View
ENSG00000085840 ORC1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.889248 View
ENSG00000169032 MAP2K1 ENSG00000170312 CDK1 H. sapiens SSL Slorth 0.889005 View
ENSG00000077721 UBE2A ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.888946 View