MAP2K1

ENSG00000169032 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004728 signal transducer, downstream of receptor, with protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0047485 protein N-terminus binding

Drugs

Drug name Description
TRAMETINIB Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Diseases

Disease Name
NSCLC
melanoma
colorectal

Orthologs

Gene Organism
PBS2 S. cerevisiae
mek-2 C. elegans
Dsor1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000136936 XPA ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.842431 View
ENSG00000108840 HDAC5 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.841733 View
ENSG00000145715 RASA1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.840665 View
ENSG00000051180 RAD51 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.840573 View
ENSG00000125952 MAX ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.840282 View
ENSG00000280548 FBL ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.83986 View
ENSG00000148835 TAF5 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.839583 View
ENSG00000169032 MAP2K1 ENSG00000183431 SF3A3 H. sapiens SSL Slorth 0.839479 View
ENSG00000149269 PAK1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.839466 View
ENSG00000169032 MAP2K1 ENSG00000213923 CSNK1E H. sapiens SSL Slorth 0.838102 View
ENSG00000053900 ANAPC4 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.837885 View
ENSG00000169032 MAP2K1 ENSG00000172534 HCFC1 H. sapiens SSL Slorth 0.837435 View
ENSG00000140443 IGF1R ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.837051 View
ENSG00000049759 NEDD4L ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.836959 View
ENSG00000169032 MAP2K1 ENSG00000185591 SP1 H. sapiens SSL Slorth 0.835795 View
ENSG00000138668 HNRNPD ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.83557 View
ENSG00000169032 MAP2K1 ENSG00000187735 TCEA1 H. sapiens SSL Slorth 0.835297 View
ENSG00000108094 CUL2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.835016 View
ENSG00000088832 FKBP1A ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.834421 View
ENSG00000169032 MAP2K1 ENSG00000185787 MORF4L1 H. sapiens SSL Slorth 0.834253 View
ENSG00000114503 NCBP2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.833379 View
ENSG00000164045 CDC25A ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.833149 View
ENSG00000130985 UBA1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.833044 View
ENSG00000104738 MCM4 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.832802 View
ENSG00000070756 PABPC1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.832359 View
ENSG00000109062 SLC9A3R1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.832018 View
ENSG00000122512 PMS2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.831173 View
ENSG00000128739 SNRPN ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.830803 View
ENSG00000164815 ORC5 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.830282 View
ENSG00000165527 ARF6 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.829704 View
ENSG00000129691 ASH2L ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.829595 View
ENSG00000169032 MAP2K1 ENSG00000170248 PDCD6IP H. sapiens SSL Slorth 0.82943 View
ENSG00000169032 MAP2K1 ENSG00000175793 SFN H. sapiens SSL Slorth 0.826318 View
ENSG00000066468 FGFR2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.825187 View
ENSG00000168883 USP39 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.825099 View
ENSG00000144554 FANCD2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.823418 View
ENSG00000106290 TAF6 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.823326 View
ENSG00000169032 MAP2K1 ENSG00000197694 SPTAN1 H. sapiens SSL Slorth 0.822221 View
ENSG00000075089 ACTR6 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.82186 View
ENSG00000063244 U2AF2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.821249 View