MAP2K1

ENSG00000169032 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004728 signal transducer, downstream of receptor, with protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0047485 protein N-terminus binding

Drugs

Drug name Description
TRAMETINIB Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Diseases

Disease Name
NSCLC
melanoma
colorectal

Orthologs

Gene Organism
PBS2 S. cerevisiae
mek-2 C. elegans
Dsor1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000169032 MAP2K1 ENSG00000183765 CHEK2 H. sapiens SSL Slorth 0.865869 View
ENSG00000169032 MAP2K1 ENSG00000173039 RELA H. sapiens SSL Slorth 0.865683 View
ENSG00000166200 COPS2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.864302 View
ENSG00000055332 EIF2AK2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.864111 View
ENSG00000133101 CCNA1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.863602 View
ENSG00000136807 CDK9 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.863264 View
ENSG00000103197 TSC2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.862604 View
ENSG00000153147 SMARCA5 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.862252 View
ENSG00000169032 MAP2K1 ENSG00000175390 EIF3F H. sapiens SSL Slorth 0.862207 View
ENSG00000112531 QKI ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.862163 View
ENSG00000115942 ORC2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.86207 View
ENSG00000136937 NCBP1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.860929 View
ENSG00000102054 RBBP7 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.858462 View
ENSG00000100387 RBX1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.857801 View
ENSG00000169032 MAP2K1 ENSG00000175104 TRAF6 H. sapiens SSL Slorth 0.857693 View
ENSG00000110713 NUP98 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.857374 View
ENSG00000106263 EIF3B ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.857305 View
ENSG00000116478 HDAC1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.8571 View
ENSG00000071564 TCF3 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.856585 View
ENSG00000169032 MAP2K1 ENSG00000173473 SMARCC1 H. sapiens SSL Slorth 0.856074 View
ENSG00000127586 CHTF18 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.856057 View
ENSG00000169032 MAP2K1 ENSG00000170004 CHD3 H. sapiens SSL Slorth 0.855569 View
ENSG00000002016 RAD52 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.854964 View
ENSG00000150459 SAP18 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.854892 View
ENSG00000026103 FAS ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.854351 View
ENSG00000136875 PRPF4 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.854199 View
ENSG00000118046 STK11 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.853344 View
ENSG00000147133 TAF1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.852522 View
ENSG00000147536 GINS4 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.852371 View
ENSG00000073969 NSF ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.851283 View
ENSG00000078043 PIAS2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.850419 View
ENSG00000126457 PRMT1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.849135 View
ENSG00000100603 SNW1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.847794 View
ENSG00000118260 CREB1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.846407 View
ENSG00000169032 MAP2K1 ENSG00000196628 TCF4 H. sapiens SSL Slorth 0.845807 View
ENSG00000119541 VPS4B ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.845488 View
ENSG00000084676 NCOA1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.845171 View
ENSG00000101343 CRNKL1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.844 View
ENSG00000106211 HSPB1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.843842 View
ENSG00000169032 MAP2K1 ENSG00000273841 TAF9 H. sapiens SSL Slorth 0.843585 View