MAP2K1

ENSG00000169032 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004728 signal transducer, downstream of receptor, with protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0047485 protein N-terminus binding

Drugs

Drug name Description
TRAMETINIB Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Diseases

Disease Name
NSCLC
melanoma
colorectal

Orthologs

Gene Organism
PBS2 S. cerevisiae
mek-2 C. elegans
Dsor1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000006451 RALA ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.91639 View
ENSG00000169032 MAP2K1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.916344 View
ENSG00000070831 CDC42 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.916274 View
ENSG00000131508 UBE2D2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.916247 View
ENSG00000058729 RIOK2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.915857 View
ENSG00000166888 STAT6 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.91583 View
ENSG00000005007 UPF1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.915827 View
ENSG00000142534 RPS11 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.915317 View
ENSG00000114391 RPL24 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.915201 View
ENSG00000166501 PRKCB ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.914944 View
ENSG00000109332 UBE2D3 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.914768 View
ENSG00000114742 WDR48 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.914651 View
ENSG00000092820 EZR ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.91448 View
ENSG00000169032 MAP2K1 ENSG00000169750 RAC3 H. sapiens SDL Slorth 0.914473 View
ENSG00000169032 MAP2K1 ENSG00000185359 HGS H. sapiens SSL Slorth 0.914452 View
ENSG00000169032 MAP2K1 ENSG00000169398 PTK2 H. sapiens SSL Slorth 0.913935 View
ENSG00000169032 MAP2K1 ENSG00000181163 NPM1 H. sapiens SSL Slorth 0.913831 View
ENSG00000135018 UBQLN1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.913628 View
ENSG00000104695 PPP2CB ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.913274 View
ENSG00000167986 DDB1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.913224 View
ENSG00000134308 YWHAQ ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.913087 View
ENSG00000150753 CCT5 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.912751 View
ENSG00000169032 MAP2K1 ENSG00000221829 FANCG H. sapiens SDL Slorth 0.912146 View
ENSG00000169032 MAP2K1 ENSG00000185345 PARK2 H. sapiens SSL Slorth 0.912121 View
ENSG00000105568 PPP2R1A ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.912032 View
ENSG00000169032 MAP2K1 ENSG00000170027 YWHAG H. sapiens SSL Slorth 0.91199 View
ENSG00000116044 NFE2L2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.911922 View
ENSG00000070756 PABPC1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.911869 View
ENSG00000116016 EPAS1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.91177 View
ENSG00000169032 MAP2K1 ENSG00000175792 RUVBL1 H. sapiens SSL Slorth 0.911618 View
ENSG00000132383 RPA1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.911528 View
ENSG00000165280 VCP ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.911514 View
ENSG00000156482 RPL30 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.91124 View
ENSG00000105173 CCNE1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.910967 View
ENSG00000154473 BUB3 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.910964 View
ENSG00000169032 MAP2K1 ENSG00000188906 LRRK2 H. sapiens SSL Slorth 0.910495 View
ENSG00000103197 TSC2 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.910306 View
ENSG00000113712 CSNK1A1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.910045 View
ENSG00000074319 TSG101 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.909969 View
ENSG00000169032 MAP2K1 ENSG00000220205 VAMP2 H. sapiens SDL Slorth 0.909943 View