MAP2K1

ENSG00000169032 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004728 signal transducer, downstream of receptor, with protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0047485 protein N-terminus binding

Drugs

Drug name Description
TRAMETINIB Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Diseases

Disease Name
NSCLC
melanoma
colorectal

Orthologs

Gene Organism
PBS2 S. cerevisiae
mek-2 C. elegans
Dsor1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000096968 JAK2 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.939893 View
ENSG00000129559 NEDD8 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.939814 View
ENSG00000169032 MAP2K1 ENSG00000196419 XRCC6 H. sapiens SSL Slorth 0.939709 View
ENSG00000169032 MAP2K1 ENSG00000172977 KAT5 H. sapiens SSL Slorth 0.93965 View
ENSG00000169032 MAP2K1 ENSG00000177885 GRB2 H. sapiens SDL Slorth 0.939621 View
ENSG00000103479 RBL2 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.939464 View
ENSG00000169032 MAP2K1 ENSG00000177189 RPS6KA3 H. sapiens SDL Slorth 0.93941 View
ENSG00000110330 BIRC2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.939114 View
ENSG00000137486 ARRB1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.938791 View
ENSG00000169032 MAP2K1 ENSG00000240771 ARHGEF25 H. sapiens SDL Slorth 0.938641 View
ENSG00000169032 MAP2K1 ENSG00000188486 H2AFX H. sapiens SSL Slorth 0.938621 View
ENSG00000135341 MAP3K7 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.938478 View
ENSG00000169032 MAP2K1 ENSG00000170345 FOS H. sapiens SSL Slorth 0.938432 View
ENSG00000169032 MAP2K1 ENSG00000184900 SUMO3 H. sapiens SSL Slorth 0.938422 View
ENSG00000062822 POLD1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.938079 View
ENSG00000124486 USP9X ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.938012 View
ENSG00000104365 IKBKB ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.937466 View
ENSG00000101966 XIAP ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.937404 View
ENSG00000132646 PCNA ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.937043 View
ENSG00000154229 PRKCA ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.936666 View
ENSG00000082701 GSK3B ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.936584 View
ENSG00000075624 ACTB ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.936517 View
ENSG00000162434 JAK1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.936425 View
ENSG00000166913 YWHAB ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.936368 View
ENSG00000154229 PRKCA ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.936309 View
ENSG00000165416 SUGT1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.936044 View
ENSG00000077097 TOP2B ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.935634 View
ENSG00000169032 MAP2K1 ENSG00000198400 NTRK1 H. sapiens SDL Slorth 0.935283 View
ENSG00000146648 EGFR ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.935232 View
ENSG00000165025 SYK ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.935079 View
ENSG00000128908 INO80 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.935041 View
ENSG00000117676 RPS6KA1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.934956 View
ENSG00000164885 CDK5 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.934942 View
ENSG00000101843 PSMD10 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.934851 View
ENSG00000108953 YWHAE ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.934751 View
ENSG00000137693 YAP1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.93437 View
ENSG00000167986 DDB1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.934298 View
ENSG00000151247 EIF4E ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.934018 View
ENSG00000159216 RUNX1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.93398 View
ENSG00000079999 KEAP1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.933716 View