MAP2K1

ENSG00000169032 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004728 signal transducer, downstream of receptor, with protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0047485 protein N-terminus binding

Drugs

Drug name Description
TRAMETINIB Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Diseases

Disease Name
NSCLC
melanoma
colorectal

Orthologs

Gene Organism
PBS2 S. cerevisiae
mek-2 C. elegans
Dsor1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000109320 NFKB1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.960492 View
ENSG00000161057 PSMC2 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.959788 View
ENSG00000169032 MAP2K1 ENSG00000256223 ZNF10 H. sapiens SDL Slorth 0.959785 View
ENSG00000124181 PLCG1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.959441 View
ENSG00000166913 YWHAB ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.959255 View
ENSG00000010810 FYN ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.958915 View
ENSG00000169032 MAP2K1 ENSG00000173039 RELA H. sapiens SDL Slorth 0.958542 View
ENSG00000168036 CTNNB1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.958263 View
ENSG00000169032 MAP2K1 ENSG00000173404 INSM1 H. sapiens SDL Slorth 0.958183 View
ENSG00000005339 CREBBP ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.958173 View
ENSG00000012048 BRCA1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.958094 View
ENSG00000169032 MAP2K1 ENSG00000198353 HOXC4 H. sapiens SDL Slorth 0.957955 View
ENSG00000097007 ABL1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.957944 View
ENSG00000167552 TUBA1A ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.95673 View
ENSG00000094804 CDC6 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.956715 View
ENSG00000103126 AXIN1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.956655 View
ENSG00000136997 MYC ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.956476 View
ENSG00000102882 MAPK3 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.95631 View
ENSG00000108443 RPS6KB1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.956201 View
ENSG00000111276 CDKN1B ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.956025 View
ENSG00000157764 BRAF ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.955687 View
ENSG00000169032 MAP2K1 ENSG00000184470 TXNRD2 H. sapiens SDL Slorth 0.955561 View
ENSG00000082701 GSK3B ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.955559 View
ENSG00000169032 MAP2K1 ENSG00000206181 TCEB3B H. sapiens SDL Slorth 0.955307 View
ENSG00000101146 RAE1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.955287 View
ENSG00000169032 MAP2K1 ENSG00000205629 LCMT1 H. sapiens SDL Slorth 0.955239 View
ENSG00000169032 MAP2K1 ENSG00000184012 TMPRSS2 H. sapiens SDL Slorth 0.954991 View
ENSG00000113575 PPP2CA ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.954748 View
ENSG00000166949 SMAD3 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.954705 View
ENSG00000097046 CDC7 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.954035 View
ENSG00000164305 CASP3 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.953923 View
ENSG00000169032 MAP2K1 ENSG00000171150 SOCS5 H. sapiens SDL Slorth 0.95354 View
ENSG00000127022 CANX ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.953454 View
ENSG00000105974 CAV1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.953377 View
ENSG00000084774 CAD ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.953333 View
ENSG00000128245 YWHAH ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.952831 View
ENSG00000141736 ERBB2 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.952788 View
ENSG00000108671 PSMD11 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.952755 View
ENSG00000124181 PLCG1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.952309 View
ENSG00000101868 POLA1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.951915 View